Decrease in Incidence of Young-Onset Colorectal Cancer Before Recent Increase

Gastroenterology
Caitlin C MurphyRobert S Sandler

Abstract

The increasing incidence of colorectal cancer in younger adults (aged <50 years) has been widely reported. Using data from the Surveillance, Epidemiology, and End Results Program, we found young-onset colorectal cancer incidence rates decreased from 1975 through about 1990. Decreases were more prominent in the colon, a contrast with more recent increases in rectal cancer. Incidence rates subsequently increased, differing by time period and 5-year age group. This inflection point is consistent with a birth cohort effect and points to early life exposures-accumulated throughout the life course-that may increase cancer risk. Studying early life exposures among persons born after 1960 may advance our understanding of colorectal cancer in younger adults.

References

Jul 6, 1994·Journal of the National Cancer Institute·K C ChuL A Ries
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Esther K WeiGraham A Colditz
Jan 27, 2005·Annals of Family Medicine·Richelle J KoopmanMark E Geesey
Feb 27, 2014·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
Mar 27, 2015·Pharmacoepidemiology and Drug Safety·Ben BoursiYu-Xiao Yang
Aug 21, 2015·Digestive Diseases and Sciences·Vincent K DikPeter D Siersema
Oct 25, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Caitlin C MurphyJohn A Baron
Jan 11, 2017·Gut·Yin CaoAndrew T Chan
May 18, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kristin WallaceElizabeth G Hill

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Citations

Mar 19, 2019·Future Oncology·Savio George Barreto
Aug 1, 2019·JAMA Network Open·Darren R BrennerRobert J Hilsden
Jan 21, 2020·Journal of the National Cancer Institute·Amanda L BlackfordMichael Goggins
Apr 24, 2020·PloS One·James VanDersliceDeborah W Neklason
Feb 4, 2019·Current Treatment Options in Gastroenterology·Anand Venugopal, Elena M Stoffel
Feb 23, 2020·Nature Reviews. Gastroenterology & Hepatology·Lorne J HofsethFranklin G Berger
May 18, 2019·Current Gastroenterology Reports·Caitlin C Murphy
May 8, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·D P StaalO Husson
May 23, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rashid N LuiJoseph J Y Sung
Nov 11, 2019·Cancer Research·Sylvain FerrandonMatthew F Kalady
Dec 18, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Don C CodipillyPrasad G Iyer
May 20, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ngozi EnweremSamir Gupta
Mar 2, 2021·World Journal of Gastrointestinal Surgery·Matteo MuellerMatthias Turina
May 1, 2021·Cells·Charles MullerSonia S Kupfer
Apr 28, 2021·Gastroenterology·Jeffrey K LeeCaitlin C Murphy
Jan 20, 2021·Journal of Clinical Gastroenterology·Daryl RamaiDouglas G Adler
May 28, 2021·JNCI Cancer Spectrum·Alexi N ArchambaultRichard B Hayes
Jul 30, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Steven H ChangPeter S Liang
Aug 21, 2021·Clinical Biomechanics·Aroj BhattaraiThanh Ngoc Tran
Aug 18, 2021·American Journal of Surgery·Swetha PrabhakaranPeter Carne
Sep 3, 2021·Critical Reviews in Food Science and Nutrition·Susana Langa, José M Landete
Aug 31, 2021·World Journal of Gastrointestinal Oncology·Joy Zhou Done, Sandy H Fang
Oct 13, 2021·Alimentary Pharmacology & Therapeutics·Fanny E R VuikManon C W Spaander
Nov 21, 2021·Nature Communications·Yongzhi YangYanlei Ma
Nov 13, 2021·American Journal of Obstetrics and Gynecology·Caitlin C MurphyBarbara A Cohn
Nov 11, 2021·Gastroenterology·Timothy A ZakiCaitlin C Murphy

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