Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis

American Journal of Obstetrics and Gynecology
H N HoY S Yang

Abstract

Our purpose was to verify regional immune modulations and to test the effect of gonadotropin-releasing hormone agonist in women with endometriosis. Concentrations of peritoneal cytokines, including interleukin-1 beta, interleukin-2, soluble interleukin-2 receptor, interleukin-6, granulocyte-monocyte colony-stimulating factor, interferon gamma, and tumor necrosis factor-alpha were compared in women with and without endometriosis. Peritoneal cytokine and interleukin-2 production were examined by adding various mitogens to peritoneal fluid mononuclear cells of women with advanced endometriosis before and after gonadotropin-releasing hormone agonist treatment. A significant increase in peritoneal interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha and a decrease in interferon gamma were noted in women with endometriosis. After gonadotropin-releasing hormone agonist treatment interleukin-6 decreased and interferon gamma increased. A significant impairment of interleukin-2 production of peritoneal fluid mononuclear cells by phytohemagglutinin and pokeweed mitogen stimulation was demonstrated in endometriosis, and production could be restored after gonadotropin-releasing hormone agonist treatment. These results indicate...Continue Reading

References

Sep 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S Tabibzadeh
Dec 1, 1989·American Journal of Obstetrics and Gynecology·J Halme
Dec 1, 1993·American Journal of Obstetrics and Gynecology·O KhorramD V Landers
Dec 1, 1993·American Journal of Reproductive Immunology : AJRI·G MelioliN Ragni
Sep 30, 1994·Annals of the New York Academy of Sciences·N A KleinR S Schenken
Jan 1, 1994·Gynecologic and Obstetric Investigation·J HirataI Nagata

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Citations

Jul 15, 2003·Mediators of Inflammation·Krzysztof SzylloAnna Kamer-Bartosinska
Sep 9, 2009·Reproductive Biology and Endocrinology : RB&E·Hongbo ZhaoYuchun Pan
Dec 31, 1997·American Journal of Reproductive Immunology : AJRI·H N HoY S Yang
Jun 17, 2011·Science Translational Medicine·Gaoping ZhaoShaoping Deng
Apr 5, 2013·Archives of Gynecology and Obstetrics·Dorota WickiewiczAnna Chełmońska-Soyta
Aug 21, 2007·Fertility and Sterility·Beata SeeberKurt T Barnhart
Apr 19, 2012·American Journal of Reproductive Immunology : AJRI·Sungwook ChunJung Gu Kim
Apr 12, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·J J KimS Y Moon
Jun 30, 2010·American Journal of Reproductive Immunology : AJRI·Yutaka OsugaYuji Taketani
May 26, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·W Paul Dmowski, Donald P Braun
Jul 23, 2015·Journal of Assisted Reproduction and Genetics·Ryan J HeitmannRichard O Burney
Jul 27, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·S LambertC Chapron
Oct 28, 2014·American Journal of Reproductive Immunology : AJRI·Akie TakebayashiTakashi Murakami
Jul 23, 2005·Human Reproduction·Chieko MorimotoYuji Taketani
Jun 1, 1997·Obstetrical & Gynecological Survey·I P Ryan, R N Taylor
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·M Y WuH N Ho
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·Ming-Yih Wu, Hong-Nerng Ho
Jan 9, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Grzegorz B GmyrekAnna Chełmońska-Soyta

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