Decrease in myosin light chain kinase activity of rabbit fast muscle by chronic stimulation

FEBS Letters
G A KlugD Pette

Abstract

Analysis of myosin light chain kinase (MLCK) activity in tibialis anterior muscles of the rabbit revealed that chronic stimulation at a frequency of 10 Hz for 24 h per day reduced the enzyme activity in a time-dependent manner. Since fast twitch muscle contains significantly more myosin light chain kinase than slow twitch muscle, the observed reductions are consistent with the type of fast-to-slow transformation observed for other type-specific muscle characteristics. The present data also indicate that the stimulation-induced decrease in MLCK activity precedes the fast-to-slow conversion of the myosin molecule as judged by pyrophosphate-polyacrylamide gel electrophoresis.

References

Feb 1, 1979·European Journal of Biochemistry·C Heilmann, D Pette
Apr 1, 1985·Pflügers Archiv : European journal of physiology·M E HoustonJ T Stull
Nov 1, 1985·Journal of Cellular Physiology·R L MooreJ T Stull
Feb 6, 1973·Pflügers Archiv : European journal of physiology·D PetteG Vrbová
Dec 1, 1984·Medicine and Science in Sports and Exercise·D Pette
Nov 1, 1984·The American Journal of Physiology·R L Moore, J T Stull
Mar 1, 1982·The American Journal of Physiology·D R Manning, J T Stull

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Citations

May 31, 1989·Biochimica Et Biophysica Acta·A Martonosi
Oct 29, 2013·Journal of Muscle Research and Cell Motility·Rene VandenboomJames T Stull
Apr 1, 1994·Pharmacology & Toxicology·Y IzumiT Hobara
Jul 6, 2004·The Journal of Experimental Biology·Cyril BozzoYvonne Mounier

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