PMID: 6191619Mar 1, 1983Paper

Decrease in natural killer cell activity in kidney allograft recipients

Annales d'immunologie
J F MoreauB Fauconnier

Abstract

The natural killer cell activity (NKCA) of a population of 66 functioning kidney allograft recipients (followed up for over 9 years) was assessed on K562 and DORA cell line targets. The 51Cr specific release test showed a rapid, sharp decrease in NKCA as early as 3 months after grafting, reaching a minimal level between 7 and 60 months (5 +/- 5 vs. 45 +/- 19% 51Cr release; P less than 0.001). Patients showing an almost total lack of NKCA were roughly the same whether assessed on K562 or DORA targets. NKCA tended to be restored in long-term transplanted patients (greater than 61 months). Control populations, aside from 32 healthy individuals, consisted of 11 haemodialysed patients as well as patients submitted to corticosteroid therapy for more than one year (8 cases of giant cell arteritis and 4 chronic asthmas). Haemodialysed patients exhibited normal NKCA (whether previously grafted or not). Corticosteroid-treated patients showed either no significant modification (K562 target) or a borderline decrease (DORA target) in NKCA. Azathioprine or corticosteroid dosage intake on the day of the test did not influence the level of graft recipient NKCA. The natural cytotoxicity of peripheral blood lymphocytes (PBL) from recipients lack...Continue Reading

References

Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ Ashby
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ P Stephens
Jan 1, 1979·Immunological Reviews·G Cudkowicz, P S Hochman
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Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·E KleinF Vánky
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Jan 1, 1980·Journal of Interferon Research·B Fauconnier

Citations

May 1, 1989·Clinical Immunology and Immunopathology·D L SiegelM B Prystowsky

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