PMID: 6191619Mar 1, 1983Paper

Decrease in natural killer cell activity in kidney allograft recipients

Annales d'immunologie
J F MoreauB Fauconnier


The natural killer cell activity (NKCA) of a population of 66 functioning kidney allograft recipients (followed up for over 9 years) was assessed on K562 and DORA cell line targets. The 51Cr specific release test showed a rapid, sharp decrease in NKCA as early as 3 months after grafting, reaching a minimal level between 7 and 60 months (5 +/- 5 vs. 45 +/- 19% 51Cr release; P less than 0.001). Patients showing an almost total lack of NKCA were roughly the same whether assessed on K562 or DORA targets. NKCA tended to be restored in long-term transplanted patients (greater than 61 months). Control populations, aside from 32 healthy individuals, consisted of 11 haemodialysed patients as well as patients submitted to corticosteroid therapy for more than one year (8 cases of giant cell arteritis and 4 chronic asthmas). Haemodialysed patients exhibited normal NKCA (whether previously grafted or not). Corticosteroid-treated patients showed either no significant modification (K562 target) or a borderline decrease (DORA target) in NKCA. Azathioprine or corticosteroid dosage intake on the day of the test did not influence the level of graft recipient NKCA. The natural cytotoxicity of peripheral blood lymphocytes (PBL) from recipients lack...Continue Reading


Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ Ashby
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ P Stephens
Jan 1, 1979·Immunological Reviews·G Cudkowicz, P S Hochman
Jan 1, 1979·Immunological Reviews·R B HerbermanP Puccetti
Oct 15, 1976·International Journal of Cancer. Journal International Du Cancer·E KleinF Vánky
Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·N L WarnerR C Burton
Jul 1, 1980·The Journal of Experimental Medicine·N MinatoB R Bloom
Jan 1, 1980·Journal of Interferon Research·B Fauconnier


May 1, 1989·Clinical Immunology and Immunopathology·D L SiegelM B Prystowsky

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.