PMID: 6172449Jan 1, 1982Paper

Decrease in peripheral sympathetic nervous system activity following renal denervation or unclipping in the one-kidney one-clip Goldblatt hypertensive rat

The Journal of Clinical Investigation
R E KatholiS Oparil

Abstract

Increased sympathetic nervous system activity has been demonstrated in established one-kidney one-clip hypertension in the rat. We have found that renal denervation in this model results in an attenuation of hypertension, unassociated with alterations in sodium or water balance or renin activity. To determine whether the depressor effect of renal denervation is associated with changes in peripheral sympathetic nervous system activity, sham operation (n = 12), renal denervation (n = 13), or unclipping (n = 13) was carried out 2 wk after the onset of one-kidney one-clip hypertension. Normotensive unine-phrectomized age- and sex-matched rats were used as controls (n = 14). Renal denervation resulted in a significant decrease in systolic blood pressure (201+/-7 to 151+/-6 mm Hg), while unclipping lowered systolic blood pressure to normotensive levels (130+/-6 mm Hg). 8 d after operation plasma norepinephrine and mean arterial pressure before and after ganglionic blockade with 30 mg/kg hexamethonium bromide were measured in conscious, unrestrained, resting animals, as indices of peripheral sympathetic nervous system activity. Plasma norepinephrine was significantly higher in hypertensive sham-operated rats (422+/-42 pg/ml) compared ...Continue Reading

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Citations

Mar 25, 2005·International Urology and Nephrology·Hippocrates Yatzidis
May 11, 2002·Current Hypertension Reports·Meryem TuncelRonald G Victor
May 11, 2002·Current Hypertension Reports·Vito M Campese, Ewa Krol
Sep 12, 2000·Current Hypertension Reports·J L Izzo, A A Taylor
Jan 10, 1993·The New England Journal of Medicine·R L ConverseR G Victor
Jul 2, 2009·Clinical and Experimental Pharmacology & Physiology·Roger G EvansNiwanthi W Rajapakse
May 18, 1999·Pharmacology & Toxicology·J S Petersen
Mar 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Sachin S Kandlikar, Gregory D Fink
Jun 8, 2012·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Ralph Knöll
Feb 19, 2011·International Journal of Hypertension·Vito M CampeseJeanie Park
Jun 22, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Sara I Al RaisiPramesh Kovoor
Mar 9, 2002·Current Hypertension Reports·John Ciriello, Cleusa V R de Oliveira
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·K TakedaH Ijichi
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·R E Katholi, W T Woods
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E Ritz, D Fliser
Apr 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E G NabelV J Dzau
Nov 6, 2015·Experimental Physiology·Elizabeth B Oliveira-SalesJulian F R Paton
Jun 1, 2000·Kidney International. Supplement·V M Campese
Jul 1, 1984·Clinical and Experimental Pharmacology & Physiology·R VandongenA Barden
May 1, 1985·Clinical and Experimental Pharmacology & Physiology·H McGowanR Vandongen
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Oct 27, 2015·BioMed Research International·Aditya BhatAlan Robert Denniss
Feb 25, 2014·Autonomic Neuroscience : Basic & Clinical·Elizabeth B Oliveira-SalesJulian F R Paton
May 11, 2013·Journal of Molecular and Cellular Cardiology·G A StoufferA L Hinderliter
Mar 12, 2011·American Journal of Hypertension·Markus P SchlaichMurray D Esler
Jul 26, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Sara I Al RaisiPramesh Kovoor
May 1, 1991·Hypertension·M Martinez-Maldonado

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