Decrease in peritoneal mast cell count in rats with adjuvant arthritis. I. Time course and interstrain difference

Agents and Actions
S SeoK Saeki


Adjuvant was injected into the left hind paw of Sprague-Dawley (SD) and Wistar rats. In SD rats a marked decrease in the mast-cell count and histamine content of the peritoneal fluid and a significant increase in the histamine content as well as the mast-cell count in the mesentery appeared between 1 and 2 weeks after adjuvant injection. This period approximately coincided with that of the development of secondary inflammatory lesions such as polyarthritis. The adjuvant-induced changes in the peritoneal fluid were more marked in SD than in Wistar rats, corresponding to more intense adjuvant arthritis in the SD strain. In Wistar rats a tendency towards an increase in the histamine content of the mesentery was observed from 2 weeks after adjuvant injection. Adjuvant injection did not have any significant effect on the histamine content of the caecum or the skin of either strain. These results show that adjuvant causes a redistribution of mast cells between the peritoneal fluid and the tissues surrounding the peritoneal cavity probably as a result of delayed hypersensitivity.


Aug 1, 1976·The Journal of Allergy and Clinical Immunology·H M Guirgis, R G Townley
Jan 1, 1978·Agents and Actions·D L WilhelmS G Watkins
Jan 1, 1955·The Journal of Pathology and Bacteriology·J F RILEY, G B WEST
Jan 1, 1963·International Archives of Allergy and Applied Immunology·B H WAKSMAN, C WENNERSTEN

Related Concepts

Mast Cell
Arthritis, Experimental
Cell Density
Rat-Bite Fever
Delayed Hypersensitivity
Peritoneal Fluid (Body Substance)

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