PMID: 2492103Jan 1, 1989Paper

Decrease in plasminogen activator correlates with synapse elimination during neonatal development of mouse skeletal muscle

Proceedings of the National Academy of Sciences of the United States of America
D HantaïB W Festoff

Abstract

Previous studies have implicated proteases, acting extracellularly, in the mechanism of polyneuronal synapse elimination. Most studies have focused on mammalian, especially rodent, skeletal muscle, where retraction of subordinate nerve terminals occurs during a narrow time window 2-3 weeks after birth. To date no specific protease(s) has been detected that (i) coincides in time with maximal synapse elimination and (ii) is known to act extracellularly on specific extracellular matrix proteins. In previous studies of denervation in adult mouse muscle, rapid activation of urokinase-type plasminogen activator, a neutral serine protease, was detected. This enzyme, by activation of plasminogen to plasmin, specifically degrades matrix components such as fibronectin, type IV collagen, and laminin in muscle. We now present evidence for an initial increase and subsequent decrease in soluble urokinase-type PA--and, to a lesser extent, tissue PA--in developing muscle, suggesting postnatal developmental regulation of these enzymes during the period of maximal synapse elimination. Although considerably higher in specific activity, membrane-bound PA activity followed the wave of synapse elimination, possibly indicating a longer half-life of m...Continue Reading

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Citations

Jan 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C W Guérin, P C Holland
Apr 1, 1994·Journal of Cellular Physiology·B W FestoffJ Chao
Sep 1, 1995·Journal of Cellular Physiology·F Vult von Steyern, J O Josefsson
Oct 1, 1996·Journal of Molecular Neuroscience : MN·B A CitronB W Festoff
Sep 17, 1993·Brain Research. Developmental Brain Research·S L BirocJ M Fisher
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R R MillerB W Festoff
Sep 25, 1999·Neuroscience Research·M TaniguchiS Yoshida
Jul 17, 1999·Brain Research. Molecular Brain Research·T SuemotoS Yoshida
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D HantaïB W Festoff
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·L J HouenouB W Festoff
Dec 1, 1991·British Journal of Haematology·M F Scully
May 7, 1990·Brain Research·F G KlierD Schubert
Jun 14, 2000·Molecular and Cellular Neurosciences·M AkaabouneD Hantaï
Mar 29, 2001·Molecular and Cellular Neurosciences·A HirataS Shiosaka
Jan 1, 1997·Molecular and Cellular Neurosciences·T P GschwendP Sonderegger
Apr 20, 2004·The European Journal of Neuroscience·Brice FarautDaniel Hantaï
Sep 10, 2005·Neuropathology and Applied Neurobiology·M DemestreN A Gregson
Feb 26, 2019·Frontiers in Neurology·Barry W Festoff, Bruce A Citron

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