Decrease in sigma but no increase in striatal dopamine D4 sites in schizophrenic brains

European Journal of Pharmacology
D M HelmesteE G Jones

Abstract

[3H]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [3H]nemonapride-labeled sigma receptor binding is decreased compared to match normal controls. No striatal dopamine D4/D4-like receptor differential was observed between the schizophrenic or control tissues, using the [3H]nemonapride minus [3H]raclopride subtraction method.

References

Mar 5, 1991·European Journal of Pharmacology·G P ReynoldsD N Middlemiss
Aug 4, 1995·European Journal of Pharmacology·G P Reynolds, S L Mason
Sep 30, 1993·Nature·P SeemanH H Van Tol
Nov 14, 1995·European Journal of Pharmacology·P SeemanH H Van Tol

❮ Previous
Next ❯

Citations

Jul 29, 2000·European Journal of Pharmacology·J KarasawaK Horikomi
Oct 18, 2000·European Journal of Pharmacology·J N OakH H Van Tol
Jul 30, 2003·Neurobiology of Aging·Kazunori KawamuraKiichi Ishiwata
Mar 9, 2000·Nuclear Medicine and Biology·K KawamuraM Senda
Apr 17, 2001·European Journal of Nuclear Medicine·V CaveliersA Bossuyt
Nov 19, 2003·The European Journal of Neuroscience·Francina LangaLluís Montoliu
Jun 30, 2000·Japanese Journal of Pharmacology·D M Helmeste, S W Tang
May 18, 1999·Biochemical and Biophysical Research Communications·Y OkuyamaT Arinami
May 1, 2021·Acta Neuropsychiatrica·Siu Wa TangBrian Leonard
May 29, 2021·RSC Medicinal Chemistry·Hebaalla Agha, Christopher R McCurdy
Feb 15, 2001·Journal of Medicinal Chemistry·M RowleyP H Hutson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.