Decrease of alpha-Hasharon globin in beta-thalassaemia

British Journal of Haematology
F ConconiL del Senno

Abstract

In time course experiments performed in subjects carrying haemoglobin Hasharon and beta-thalassaemia the synthesis of alphaA-, alphaHasharon-, beta- and gamma-globin has been determined. The alpha-globin molecules synthesized in excess were found to be removed from the red cell cytoplasm (phenomenon characteristic of beta-thalassaemia, described by Bargellesi et al, 1968a); in addition the alphaHasharon-globin molecules were removed at a faster rate than normal alpha-globin. The preferential removal of the mutant alpha-globin explains the reduced level of haemoglobin Hasharon found in subjects carrying the gene for beta-thalassaemia (Alberti et al, 1975). Reductions below normal levels of other haemoglobin variants occurring in the presence of the counterpart-globin thalassaemia are probably determined through a similar mechanism.

References

Sep 1, 1975·Journal of Medical Genetics·R AlbertiL Tenteri
May 1, 1975·British Journal of Haematology·M H SteinbergB J Dreiling
Jul 1, 1975·British Journal of Haematology·M H Steinberg
Mar 1, 1967·European Journal of Biochemistry·A BargellesiF Conconi
Jan 1, 1974·Humangenetik·H Lehmann, F Vella
Feb 1, 1972·The Journal of Clinical Investigation·R F Rieder
Nov 20, 1969·Annals of the New York Academy of Sciences·S PontremoliF Conconi
Dec 1, 1968·European Journal of Biochemistry·A BargellesiF Conconi
May 1, 1969·The Journal of Clinical Investigation·S CharacheU Gessner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.