Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement

Annals of the Rheumatic Diseases
C AlessandriG Valesini

Abstract

To investigate the effect of infliximab treatment on anti-cyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) in patients with rheumatoid arthritis. 43 patients with rheumatoid arthritis not responding to disease modifying anti-rheumatic drugs (DMARD) received intravenous infliximab at a dose of 3 mg/kg at baseline and after two and six weeks, and subsequently bimonthly, in combination with methotrexate. Serum samples were collected at baseline and at week 24. A commercial enzyme linked immunosorbent assay was used to test for anti-CCP antibodies; RF were detected using a quantitative nephelometric assay. At baseline, 38 of the 43 patients (88%) were positive for anti-CCP antibodies, and 41 (95%) were positive for RF. The serum titre of anti-CCP and RF decreased significantly after six months of treatment (p = 0.0001 and p<0.0001, respectively). When the patients were grouped on the basis of their clinical response to infliximab, a significant decrease in serum anti-CCP antibodies and RF was observed only in patients who had clinical improvement (ACR 20 and ACR 50). Anti-TNFalpha treatment in rheumatoid arthritis results in a decrease in the serum titres of RF and anti-CCP antibodies in patients showin...Continue Reading

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Citations

Jan 14, 2010·Clinical Rheumatology·Andrea Tesija-KunaNada Vrkic
Feb 14, 2008·Clinical Reviews in Allergy & Immunology·Cristiano AlessandriGuido Valesini
Oct 28, 2008·La Presse médicale·Nicole FabienUNKNOWN Groupe d'Etude de l'Auto-Immunité
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Jun 2, 2009·Rheumatology·Carine BansardXavier Le-Loët
Nov 26, 2009·Rheumatology·Tineke CantaertDominique L Baeten
Nov 3, 2006·Annals of the Rheumatic Diseases·Francesca Bobbio-PallaviciniCarlomaurizio Montecucco
Jan 5, 2008·Annual Review of Immunology·Lars KlareskogLars Alfredsson
Apr 24, 2007·BMC Musculoskeletal Disorders·Ioannis AlexiouLazaros I Sakkas
Feb 16, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Rudolf Mierau, Ekkehard Genth
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Jul 6, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yuji NozakiMasanori Funauchi
Nov 3, 2011·Pharmacogenomics·Rita PrajapatiAnne Barton
Jul 20, 2007·Pharmacogenomics·Marieke J H CoenenBarbara Franke
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Jul 8, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Anaïs GardettePhilippe Dieudé

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