PMID: 6988274Jan 1, 1980Paper

Decrease of antibodies to insulin, proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin

Diabetologia
A B KurtzJ D Nabarro

Abstract

The sera of 30 patients who had been treated with conventional beef insulin were tested for binding of insulin and other pancreatic hormones. All showed antibody binding of insulin, 29 binding of proinsulin, 29 binding of pancreatic polypeptide, two binding of glucagon but none of the sera bound vasoactive intestinal peptide or somatostatin. After changing therapy to highly purified pork insulin the binding capacity of sera for insulin and the other hormones was monitored for up to 35 months and a steady fall was found in nearly all cases. In eight of the patients conventional beef insulin treatment was resumed: in one month binding of insulin and of the other hormones increased back to the initial levels. In eighteen subjects who had only received highly purified pork insulin low levels of insulin binding were found with no binding of proinsulin or other hormones. The amounts of proinsulin and contaminating hormones in highly purified pork insulin are so low that they are not immunogenic; conventional beef insulin not only contains immunogenic amounts of proinsulin and the contaminating hormones pancreatic polypeptide and glucagon but also is more immunogenic than purified pork insulin.

References

Jun 19, 1976·Lancet·J G Devlin, V Parameswaran
Nov 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D AndreaniC Maltarello
Jan 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D Kumar, L V Miller
Jan 1, 1972·Diabetes·J SchlichtkrullK H Jorgensen
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Mar 1, 1970·The Journal of Clinical Investigation·F MelaniD F Steiner

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Citations

Dec 10, 1999·Diabetes/metabolism Research and Reviews·O Vaarala
Oct 1, 1980·Diabetologia·A B Kurtz, J D Nabarro
Oct 1, 1982·Acta diabetologica latina·E R RichensM Hartog
Sep 1, 1983·Irish Journal of Medical Science·M I DruryL S Gerlis
Jan 21, 1985·Journal of Immunological Methods·T WilkinC Casey
Jun 20, 1992·Lancet·T BockK Buschard
May 3, 1984·The New England Journal of Medicine·D C RobbinsA H Rubenstein
Jul 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·E ChantelauA A Starke
May 1, 1982·The British Journal of Ophthalmology·R S GrayB F Clarke
Oct 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·U B EricssonJ I Thorell
Aug 30, 2008·Biosensors & Bioelectronics·Jenny CarlssonBo Liedberg
May 8, 2007·Journal of Immunological Methods·Sarah L HaywardJohn F Elliott
Sep 22, 2009·Diabetes/metabolism Research and Reviews·Naru BabayaGeorge S Eisenbarth
Oct 4, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Minna TiittanenUNKNOWN Finnish TRIGR Study Group
Nov 30, 2006·Annals of the New York Academy of Sciences·Outi Vaarala
Jan 18, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yariv YogevRaoul Orvieto
Feb 1, 1986·Metabolism: Clinical and Experimental·N J VaughanG S Spathis
Aug 1, 1986·Clinical Immunology and Immunopathology·S MerynW A Bauman
Nov 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·R S GrayL J Duncan
Jan 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·R S GrayB F Clarke
May 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·J S Corcoran, J S Yudkin
Jul 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·J L Diaz, T Wilkin
Jan 1, 2015·Expert Review of Endocrinology & Metabolism·Jorma IlonenOuti Vaarala
May 22, 2002·Annals of the New York Academy of Sciences·Outi Vaarala
Jul 1, 1984·Scottish Medical Journal·R S GrayR A Elton
Oct 31, 1997·Journal of Autoimmunity·A J WilliamsE A Gale
Dec 5, 1998·Annals of Clinical Biochemistry·A CasesnovesA M Picó

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