Decrease of atazanavir and lopinavir plasma concentrations in a boosted double human immunodeficiency virus protease inhibitor salvage regimen.

Antimicrobial Agents and Chemotherapy
Nils von HentigJörn Lötsch

Abstract

The human immunodeficiency virus protease inhibitor combination of atazanavir (ATV)-lopinavir-ritonavir was reported to exhibit a mutual pharmacoenhancement of plasma lopinavir and ATV concentrations which may be beneficial for salvage patients. We identified 17 patients in our pharmacokinetic database taking this combination and found conflicting results. Plasma concentrations of both ATV and lopinavir were modestly, although not significantly, decreased when the drugs were coadministered. Therefore, patients should be selected carefully for this regimen and frequent clinical and therapeutic drug monitoring is strongly advised.

References

Feb 19, 2005·Health & Social Care in the Community·Blake PolandGail Yardy
Feb 14, 2007·Antimicrobial Agents and Chemotherapy·Nils von HentigSchlomo Staszewski
Apr 7, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Paul A PhamPatricia Barditch-Crovo
Apr 27, 2007·Drugs of Today·Nils von Hentig
Aug 1, 2007·European Journal of Clinical Pharmacology·Nils von HentigSebastian Harder

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Citations

Nov 1, 2008·Drugs·Esteban Ribera, Adrian Curran
Dec 5, 2008·Expert Review of Anti-infective Therapy·Robin Wood
Oct 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Danièle Bentué-FerrerEric Bellissant
Nov 13, 2009·HIV Clinical Trials·Chris R RathbunEdward P Acosta
Mar 10, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nuggehally R Srinivas
Sep 14, 2011·Therapeutic Drug Monitoring·Elena López AspirozMaría José García Sánchez

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