Decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function in untreated ulcerative colitis patients

Autoimmunity
Mousa Mohammadnia-AfrouziIradj Maleki

Abstract

Regulatory T (Treg) cells take part in immune homeostasis and play a pivotal role in maintaining peripheral tolerance. The aim of this study was to evaluate the frequency and function of Treg cells in active and untreated ulcerative colitis (UC) patients. Thirty-two subjects with newly diagnosed UC and 31 age-matched healthy controls were included in this survey. The frequency of Tregs was analyzed with flow cytometry using CD4, CD25, CD127 and FoxP3 markers. We used surface expression of CD4(+), CD25(+) and CD127(low) markers for isolation of a relatively pure Treg population. Suppressive activity of Tregs was determined by measuring their ability to inhibit the proliferation of T responder cells. UC patients had a lower frequency of CD4(+) CD25(+) CD127(low) FoxP3(+) Treg cells. Additionally, Treg cell-mediated suppression was lower in UC patients compared to controls. The frequency and suppressive capacity of Tregs and MFI of FoxP3 were inversely correlated with disease activity. These results suggest that CD4(+) CD25(+) CD127(low) FoxP3(+) Treg cells may contribute to immunopathogenesis of UC, and assessment of Treg cell frequency and function may have clinical value.

References

Jun 30, 1994·The New England Journal of Medicine·S LichtigerS Hanauer
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Jul 24, 2003·Nature Reviews. Immunology·Gerd Bouma, Warren Strober
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Jan 9, 2007·Inflammatory Bowel Diseases·Qi T YuKonstantinos A Papadakis
Apr 19, 2007·Nature Immunology·Ye Zheng, Alexander Y Rudensky
Jun 15, 2007·The Surgical Clinics of North America·M Nedim Ince, David E Elliott
Feb 26, 2008·Journal of Gastroenterology·Atsushi Mizoguchi, Emiko Mizoguchi
Apr 9, 2008·European Journal of Immunology·Shimon Sakaguchi
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunil K ChauhanReza Dana
Nov 26, 2009·Journal of Clinical Immunology·Nicola Eastaff-LeungSimon Barry
Apr 15, 2010·Autoimmunity·Silvia Melgar, Fergus Shanahan
Nov 26, 2010·Autoimmunity·Elaine V Lourenço, Antonio La Cava
Jul 28, 2011·Journal of Digestive Diseases·Yi WangCheng Gong Yu
Mar 1, 2012·Journal of Gastroenterology·Kuo-Chih TsengShu-Fen Wu

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Citations

May 22, 2016·Autoimmunity·Mark Plander, Bernadette Kalman
Jul 10, 2016·Asian Pacific Journal of Tropical Medicine·Gui-Yun JinChao-Qian Li
Jul 17, 2016·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Aug 16, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabiola PuentesOlaf Rötzschke
Sep 14, 2016·Journal of Pediatric Gastroenterology and Nutrition·Ana Savić MlakarKrešo Bendelja
Mar 10, 2020·Immunological Reviews·Haiping WangPing-Chih Ho
Aug 25, 2020·MedComm·Yu LiuSong Guo Zheng
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Aug 23, 2020·International Journal of Molecular Sciences·Rodrigo de Oliveira FormigaLeônia Maria Batista
Jul 4, 2020·Mediators of Inflammation·Xueyan DingGuoqiang Zhu
Nov 26, 2020·Annual Review of Pathology·Rheinallt M Jones, Andrew S Neish
Feb 18, 2018·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Ali KhaliliMousa Mohammadnia Afrouzi
Feb 18, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mehdi Soltanzadeh-YamchiMousa Mohammadnia-Afrouzi

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