Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats.

Journal of Biomedicine & Biotechnology
Meng-Fu ChengJuei-Tang Cheng

Abstract

The klotho gene is expressed in a limited number of tissues, most notably in distal convoluted tubules in the kidney and choroid plexus in the brain. A previous study suggested that Klotho increases resistance to oxidative stress. However, changes of Klotho expression in high glucose-induced oxidative stress remain unclear. In the present study, we used streptozotocin-induced diabetic rats (STZ rats) to examine the effects of insulin, phloridzin or antioxidant, tiron on diabetic nephropathy. Both insulin and phloridzin reversed the lower Klotho expression levels in kidneys of STZ rats by the correction of hyperglycemia. Also, renal functions were improved by these treatments. In addition to the improvement of renal functions, the decrease of Klotho expression in kidney of STZ rats was also reversed by tiron without changing blood glucose levels. The reduction of oxidative stress induced by high glucose can be considered for this action of tiron. This view was further confirmed in vitro using high glucose-exposed Madin-Darby canine kidney (MDCK) epithelial cells. Thus, we suggest that decrease of oxidative stress is not only responsible for the improvement of renal function but also for the recovery of Klotho expression in kidne...Continue Reading

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Citations

Jan 4, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·María C IzquierdoAlberto Ortiz
Sep 10, 2014·Journal of Diabetes and Metabolic Disorders·Mohammad Reza ParviziMansoor Keshavarz
Aug 25, 2012·Journal of Biomedicine & Biotechnology·Min-Tser LiaoKuo-Cheng Lu
Mar 8, 2013·Seminars in Nephrology·Ming Chang HuOrson W Moe
Dec 1, 2010·Kidney International·Sistiana Aiello, Marina Noris
Jan 25, 2013·Experimental Diabetes Research·Naoaki SakataMichiaki Unno
Jul 28, 2012·Clinical Biochemistry·Ina Maria KacsoGabriel Kacso
Jun 22, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ayca InciNecat Yılmaz
Mar 23, 2017·Ageing Research Reviews·Marina Minto Cararo-LopesDaniel Charles Berwick
Oct 18, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah L BarkerSachdev S Sidhu
Apr 11, 2017·Clinical and Experimental Pharmacology & Physiology·Ping JiangChanghua Wang
Nov 21, 2015·Clinical and Experimental Nephrology·Hiroyuki KadoyaNaoki Kashihara
Jul 27, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Priya RavikumarOrson W Moe
Apr 12, 2018·American Journal of Physiology. Renal Physiology·Hyung Jung OhSeung Hyeok Han
Jul 9, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Feng Yu KuoCheng-Chia Tsai
Aug 4, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Ho-Shan NiuJuei-Tang Cheng
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Yabing Xiong, Lili Zhou
Aug 15, 2019·American Journal of Physiology. Renal Physiology·Hyung Jung OhYong Eun Chung
Nov 4, 2020·Life Sciences·Ajinath KaleAnil Bhanudas Gaikwad

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