Abstract
The inappropriate insulin release that is characteristic of severe neonatal hypoglycemia and nesidioblastosis was thought to be principally due to a marked proliferation of B-cells. A possible deficiency of somatostatin, one of the factors controlling insulin release, has only recently been considered. We report have a significant decrease of pancreatic somatostatin cells and somatostatin content in nesidioblastosis, as compared with appropriate controls. Pancreatic tissue from five babies with severe hypoglycemia, hyperinsulinemia, and nesidioblastosis was examined for insulin, somatostatin, and glucagon by immunocytochemistry and radioimmunoassay. There was a variable insulin cell hyperplasia among the nesidioblastotic specimens but no significant difference from controls was detected. In contrast, there was a consistent and highly significant (P less than 0.02) decrease (of more than 50%) of somatostatin cells (controls, 1.29 +/- 0.22%; nesidioblastosis, 0.53 +/- 0.14%, mean +/- SEM). Similarly, there was no significant alteration in insulin content, although a slight increase was found in non-microadenomatous areas of the diseased pancreata (controls, 42.3 +/- 4.1; nesidioblastosis, 58.6 +/- 9.4 nmol/g wet weight of tissue,...Continue Reading
Citations
Aug 1, 1990·Diabetologia·N KaiserE Cerasi
Oct 1, 1988·World Journal of Surgery·C G ThomasC N Carney
Oct 15, 1984·Experientia·D Pipeleers
Sep 1, 1984·Annals of Surgery·L W MartinC A Sheldon
May 1, 1996·Archives of Disease in Childhood·R D Milner
Feb 24, 2000·Archives of Disease in Childhood. Fetal and Neonatal Edition·J RahierC Sempoux
Oct 1, 1984·Journal of Clinical Pathology·P J Dunn
Jul 1, 1990·Journal of Medical Genetics·P A McKeever, I D Young
May 1, 1992·Postgraduate Medical Journal·R AndrewsW J Jeffcoate
Aug 15, 1984·Experientia·A E BishopJ M Polak
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D BaniG Biliotti
Jan 1, 1983·Pediatric Pathology·V E GouldN S Gould
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·J M Polak, S R Bloom
Nov 1, 1989·Baillière's Clinical Endocrinology and Metabolism·A Aynsley-Green
Sep 23, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·M M JackJ R Bell
Sep 10, 2017·Scientific Reports·Jean-Claude HenquinJacques Rahier
Jan 1, 1984·The British Journal of Surgery·M H Gough
Jan 1, 1986·Pediatric Pathology·K Soejima, B H Landing
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·C SempouxJ Rahier
Mar 1, 1982·Klinische Wochenschrift·D Grube