Decrease of transferrin C2 frequency with age

Human Heredity
L E Beckman, G Beckman

Abstract

In previous studies, transferrin C2 has been found to be associated with spontaneous abortion, prematurity, phototoxic eczema and rheumatoid arthritis. We have suggested that the mechanism behind these negative effects may be that transferrin C2 increases the risk for damage through hydroxyl radicals. This hypothesis predicts that the C2 frequency should decrease with age. Such an effect is demonstrated in this report. In a population from northern Sweden the C2 gene frequency was found to decrease from 0.173 in newborns to 0.099 in 70-year-old healthy individuals.

Citations

Dec 26, 2001·Neuroscience Letters·Rafiqul I HussainChristopher M Morris
Nov 29, 2011·Journal of the Neurological Sciences·Eliška MarklováMartin Vališ
Jun 25, 2005·Biochimica Et Biophysica Acta·Paolo ZattaChiara Gabbiani
Nov 1, 1988·Ergonomics·L Hardy, D Nelson

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