Decreased 19S antibody response to bacterial antigens in systemic lupus erythematosus

The Journal of Clinical Investigation
J Baum, M Ziff

Abstract

The antibody response to immunization with Brucella and the levels of natural antibody to Escherichia coli and Shigella were compared in patients with systemic lupus erythematosus and control groups. After Brucella immunization, SLE patients showed a significantly lower antibody response in whole serum and in the macroglobulin antibody fraction separated by sucrose density gradient centrifugation. Sucrose gradient fractionation of natural antibodies to E. coli and a polyvalent Shigella antigen showed a significant decrease in macroglobulin antibody against four of the five E. coli antigens tested and the Shigella polyvalent antigen in SLE patients when compared with a group of normal individuals and a matched control group with pulmonary tuberculosis. Whole serum natural antibody titers against 5 of 13 Shigella antigens were significantly lower in the SLE patients when compared with the normal group, and against 7 of 13 when compared with the matched tuberculosis controls. Whole serum titers against 8 of 13 E. coli antigens were significantly lower in the SLE patients when compared with normal subjects. The observed decreased antibody response to bacterial antigens in SLE patients, occurring mainly in the macroglobulin fraction...Continue Reading

References

Apr 1, 1967·British Medical Journal·A R McGivenR C Nairn
Apr 29, 1967·British Medical Journal·J D Coghlan, D M Weir
Dec 1, 1967·American Journal of Public Health and the Nation's Health·V M YoungD M Kenton
Feb 1, 1966·Journal of Chronic Diseases·R R Carpenter, B C Sturgill
Apr 1, 1953·Annals of Internal Medicine·R A JESSARC RAGAN
Nov 6, 1954·Journal of the American Medical Association·P A TUMULTY
Mar 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·L H MUSCHEL
Sep 1, 1961·Archives of Dermatology·I SARKANY
Oct 1, 1963·The Journal of Experimental Medicine·J G MICHAEL, F S ROSEN
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·M A SHEARNE P ENGLEMAN
Jun 1, 1964·The Journal of Clinical Investigation·E V BARNETTJ H VAUGHAN
Oct 1, 1964·The American Journal of Medicine·C GILBERT, R HONG
Jun 17, 1965·The New England Journal of Medicine·J L REDDINW W SPINK
Oct 1, 1961·The Journal of Clinical Investigation·L E MEISELASM SIEGEL
Jul 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·P PerlmannD Campbell

❮ Previous
Next ❯

Citations

Oct 20, 1998·Arthritis and Rheumatism·D F BattafaranoR J Enzenauer
May 1, 1970·Arthritis and Rheumatism·K K BandillaF C McDuffie
Jan 1, 1974·Arthritis and Rheumatism·P J StaplesR S Gordon
Jul 1, 1974·Arthritis and Rheumatism·R P Messner
May 1, 1975·Arthritis and Rheumatism·M W YocumJ J Condemi
Mar 1, 1974·Annals of the Rheumatic Diseases·R A ClarkJ L Decker
Feb 1, 1982·Annals of the Rheumatic Diseases·P H Feng, T H Tan
Jul 1, 1988·Annals of the Rheumatic Diseases·L Turner-Stokes, D A Isenberg
Jan 8, 1977·British Medical Journal·E JohanssonT Rostila
Sep 11, 1971·British Medical Journal·A G Mowat, J Baum
Feb 1, 1974·The Journal of Clinical Investigation·H E JasinM Ziff
Dec 1, 1990·Seminars in Arthritis and Rheumatism·S R MitchellP Katz
Feb 1, 1976·The American Journal of Medicine·M B UrowitzM A Ogryzlo
Dec 12, 1975·Die Medizinische Welt·E M Lemmel
Jan 1, 1978·Scandinavian Journal of Rheumatology·I AlvarezJ A Ojeda
Dec 1, 1979·The American Journal of Medicine·N I StahlJ L Decker
Apr 1, 1981·International Journal of Dermatology·J D Taurog, A D Steinberg
Jan 1, 1973·Scandinavian Journal of Rheumatology·B Svensson, H Hedberg
Jan 1, 1987·Scandinavian Journal of Rheumatology·J Baum
Dec 1, 1970·CRC Critical Reviews in Clinical Laboratory Sciences·F P Quismorio, G J Friou
Dec 1, 1979·Arthritis and Rheumatism·J H KlippelG Schiffman
Nov 1, 1980·Arthritis and Rheumatism·M P JarrettA I Grayzel
Jun 2, 1998·Rheumatic Diseases Clinics of North America·M Petri
May 22, 1970·Science·P E Phillips, C L Christian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.