Decreased [(3)H]spiperone binding in the anterior cingulate cortex of schizophrenia patients: an autoradiographic study

Neuroscience
K Zavitsanou, X F Huang

Abstract

Abnormalities in the anterior cingulate cortex have been reported in patients with schizophrenia, and have been implicated in the pathophysiology of this disorder. In the present study, we have examined antipsychotic-sensitive binding sites in the left anterior cingulate cortex of schizophrenia patients and controls. Using quantitative autoradiography and [(3)H]spiperone as a ligand, both saturation and competition experiments were performed in post-mortem brain tissue obtained from six schizophrenia and six control cases. Saturation experiments revealed that the maximum number of [(3)H]spiperone binding sites was significantly reduced by 31% in the schizophrenia group as compared to the control group (65.3+/-5.6 fmol/mg tissue versus 94.2+/-7.3 fmol/mg tissue). Increased dissociation constant was also observed in the schizophrenia group (2.2+/-0.4 nM versus 1.3+/-0.2 nM), but was not statistically significant (P=0.07). Competition experiments were performed in order to examine the pharmacological profile of [(3)H]spiperone binding, and revealed that: (i) displacement of [(3)H]spiperone binding by clozapine and mianserin was significantly reduced in the schizophrenia group as compared to the control group (-26% and -16% respect...Continue Reading

Citations

Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Daren M DraganicVaughan J Carr
Apr 1, 2009·International Journal of Molecular Sciences·Irina DedovaClive G Harper
Dec 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katerina ZavitsanouHuang Xu-Feng
Apr 1, 2015·PloS One·Courtney R SullivanRobert E McCullumsmith
Jul 12, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Teresa M du BoisXu-Feng Huang
Jul 12, 2005·Life Sciences·K Yaragudri Vinod, Basalingappa L Hungund

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