Decreased 4-1BB expression on CD4+CD25 high regulatory T cells in peripheral blood of patients with multiple sclerosis.

Clinical and Experimental Immunology
G-Z LiuP Hjelmström

Abstract

As a tumour necrosis factor receptor superfamily member, 4-1BB (CD137) is preferentially expressed in CD4+CD25+ regulatory T cells (Tregs) and has been suggested to play an important role in regulating the generation or function of Tregs. Recent studies of human Tregs have shown that blood CD4+CD25(high) T cells were much closer to Tregs in terms of their functionality. Furthermore, CD4+CD25(high) Tregs have been found to have a decreased effector function in patients with multiple sclerosis (MS). In this study, we examined the expression of 4-1BB and soluble 4-1BB (s4-1BB) protein levels in the peripheral blood of MS patients. Compared with healthy controls, MS patients had decreased 4-1BB expression in their CD4+C25(high) Tregs and increased plasma s4-1BB protein levels. Moreover, the plasma s4-1BB levels of MS patients were shown to be inversely correlated with the 4-1BB surface expression of CD4+CD25(high) Tregs. The down-regulated 4-1BB expression on CD4+CD25(high) Tregs of MS patients may be involved in the impaired immunoactivity of these Tregs. The elevated s4-1BB levels may, at least in part, function as a self-regulatory attempt to inhibit antigen-driven proliferation of Tregs or their immunosuppressive activity.

References

Apr 12, 2001·European Journal of Immunology·L A StephensF Powrie
May 24, 2001·Current Opinion in Neurology·R Hohlfeld, H Wekerle
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Baecher-AllanD A Hafler
Dec 12, 2001·Nature Immunology·Marc A GavinAlexander Rudensky
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M K Sharief
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yonglian SunYang-Xin Fu
Mar 20, 2002·Current Neurology and Neuroscience Reports·S Markovic-Plese, H F McFarland
Jun 19, 2002·Blood·Simona RonchettiPier Paolo Pandolfi
Nov 1, 2003·Annals of the New York Academy of Sciences·A BalandinaS Berrih-Aknin
Dec 25, 2003·Journal of Leukocyte Biology·Beom K ChoiByoung S Kwon
Mar 3, 2004·European Journal of Immunology·Simona RonchettiCarlo Riccardi
Apr 7, 2004·The Journal of Experimental Medicine·Vissia VigliettaDavid A Hafler
Apr 8, 2004·Human Molecular Genetics·David A DymentUNKNOWN Canadian Collaborative Study Group
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-bin JiCox Terhorst
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guoxing ZhengAoshuang Chen
Dec 8, 2004·American Journal of Human Genetics·Ann B BegovichJorge R Oksenberg
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki SugiyamaKevin D Cooper
Mar 26, 2005·Immunological Reviews·David A HaflerClare Baecher-Allan
Jun 28, 2005·Trends in Immunology·Lara M Myers, Anthony T Vella
Dec 6, 2005·Journal of Neuroimmunology·Richard H RoxburghAlastair Compston
Mar 1, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Petra HoffmannMatthias Edinger
Mar 4, 2006·Brain : a Journal of Neurology·Mariusz StasiolekKrzysztof Selmaj
Aug 15, 2006·Immunological Reviews·Jens LohrAbul K Abbas
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xavier ValenciaPeter E Lipsky
Apr 5, 2007·European Journal of Immunology·Giuseppe NocentiniCarlo Riccardi
Jun 15, 2007·Lancet Neurology·Sreeram Varadharajan RamagopalanUNKNOWN Canadian Collaborative Study Group
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser

❮ Previous
Next ❯

Citations

Mar 28, 2012·Acta neurologica Belgica·R E Gonsette
Jul 7, 2011·PloS One·Dacia Dalla LiberaRoberto Furlan
Jun 10, 2010·Folia Histochemica Et Cytobiologica·Włodzimierz ŁuczyńskiArtur Bossowski
Oct 3, 2015·Expert Opinion on Therapeutic Targets·Dass S Vinay, Byoung S Kwon
Nov 29, 2008·Clinical and Experimental Immunology·J M LawsonT I M Tree
Oct 27, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Risa K Benwell, David R Lee
Aug 24, 2010·Critical Reviews in Oncology/hematology·Young-June Kim, Hal E Broxmeyer
Oct 27, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Guliang XiaBryon D Johnson
Aug 29, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Karin EnarssonMarianne Quiding-Järbrink
Jan 4, 2006·Clinical Neurology and Neurosurgery·Nikolaos GrigoriadisDimitrios Karussis
Apr 14, 2010·Scandinavian Journal of Immunology·W ŁuczyńskiL Chyczewski
Jun 10, 2010·American Journal of Reproductive Immunology : AJRI·Amolak Singh Bansal
Feb 3, 2011·Immunopharmacology and Immunotoxicology·Farhad Jadidi-Niaragh, Abbas Mirshafiey
Oct 16, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kritika KachapatiWilliam M Ridgway
Oct 5, 2010·Journal of the Neurological Sciences·Z MikulkovaJ Michalek

❮ Previous
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