PMID: 6539875Jul 1, 1984Paper

Decreased 6-hydroxymelatonin excretion in Korsakoff's psychosis

Neurology
P R MartinS P Markey

Abstract

Mean (+/- SEM) urinary excretion rate of the major melatonin metabolite 6-hydroxymelatonin (micrograms/day) was lower in 7 (2.8 +/- 1.0) of 8 men with Korsakoff's psychosis (KP) than in 15 healthy men (11.4 +/- 1.4). Treatment with the alpha 2-noradrenergic agonist clonidine decreased daily 6-hydroxymelatonin excretion (p less than 0.02). Reduced daily excretion of 6-hydroxymelatonin in KP reflects decreased melatonin synthesis in the pineal gland, perhaps as a residual effect of lesions due to past thiamine deficiency (Wernicke's encephalopathy).

Citations

Jan 1, 1991·Psychopharmacology·W J McEntee, T H Crook
Nov 1, 1988·Biological Psychiatry·J A HamiltonS Pinkel
Aug 1, 1990·Trends in Neurosciences·W J McEntee, R G Mair
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·P R MartinM J Eckardt
Aug 17, 1989·The New England Journal of Medicine·M E CharnessD A Greenberg
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·P R MartinC K Singleton
Apr 1, 1991·Journal of Pineal Research·G M BrownS M Yie
Nov 26, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Eduardo Alves de AlmeidaS R Pandi-Perumal
Jan 1, 1991·The International Journal of Neuroscience·R Sandyk
Nov 1, 1992·The International Journal of Neuroscience·R Sandyk, G I Awerbuch
Nov 1, 1991·The International Journal of Neuroscience·J D Kanofsky, R Sandyk
Jul 1, 1986·The Journal of Pharmacy and Pharmacology·A J LewyS P Markey
Mar 2, 2018·Journal of Sleep Research·Susanna MantovaniJohn D O'Sullivan
Sep 1, 1993·Acta Psychiatrica Scandinavica·J H Thakore, T G Dinan
Jun 1, 1989·Alcoholism, Clinical and Experimental Research·P R MartinJ Karanian
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·P K Thomas
Mar 15, 1985·Science·P R MartinM J Eckardt

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