Abstract
Adipose tissue (AT) autophagy gene expression is elevated in human obesity, correlating with increased metabolic risk, but mechanistic links between the two remain unclear. Thus, the objective of this study was to assess whether elevated autophagy may cause AT endocrine dysfunction, emphasizing the putative role of adiponectin in fat-liver endocrine communication. We utilized a large (N=186) human AT biobank to assess clinical associations between human visceral AT autophagy genes, adiponectin and leptin, by multivariate models. A broader view of adipocytokines association with elevated autophagy was assessed using adipocytokine array. Finally, to establish causality, ex vivo studies utilizing a murine AT-hepatocyte cell line co-culture system was used. Circulating high-molecular-weight adiponectin and leptin levels were associated with human omental-AT expression of ATG5 mRNA, associations that remained significant (β=-0.197, P=0.011; β=0.267, P<0.001, respectively) in a multivariate model adjusted for age, sex, body mass index and interleukin-6 (IL-6). A similar association was observed with omental-AT LC3A mRNA levels. Bafilomycin-A1 (Baf A) pretreatment of AT explants from high-fat-fed (HFF) mice had no effect on the secret...Continue Reading
References
Feb 24, 2007·Endocrinology·Nava BashanAssaf Rudich
Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Ilana Harman-BoehmAssaf Rudich
Oct 3, 2008·PloS One·Zhi-Hua ChenAugustine M K Choi
Nov 27, 2008·American Journal of Physiology. Endocrinology and Metabolism·Julia KovsanAssaf Rudich
Feb 18, 2009·The Journal of Clinical Investigation·Anurag Kumar SinghUrsula Seidler
Apr 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Matthias BlüherAssaf Rudich
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhangShengkan Jin
Jan 30, 2010·Autophagy·Scott GoldmanShengkan Jin
Apr 14, 2010·Molecular Medicine·Anita OstPeter Strålfors
Jun 4, 2010·Cell Metabolism·Ling YangGökhan S Hotamisligil
Jul 28, 2010·Endocrinology·Ori NovAssaf Rudich
Sep 25, 2010·Autophagy·Lijun Zhou, Feng Liu
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Julia KovsanAssaf Rudich
Dec 14, 2011·Biochemical and Biophysical Research Communications·Takeshi YoshizakiHiroshi Maegawa
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun
Oct 31, 2012·Obesity Facts·Nitzan MaixnerAssaf Rudich
Nov 3, 2012·Endocrinology·H J JansenR Stienstra
Jan 24, 2013·PloS One·Ori NovAssaf Rudich
Feb 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Hagit ShapiroAssaf Rudich
Feb 15, 2013·The New England Journal of Medicine·Augustine M K ChoiBeth Levine
Mar 13, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C E NuñezE P Araujo
Dec 10, 2013·Cell Metabolism·Xiaoyuan XuAnthony W Ferrante
May 6, 2014·Diabetologia·Rinke StienstraGil Leibowitz
Mar 31, 2015·Molecular and Cellular Endocrinology·J KosackaM Blüher
Jun 4, 2015·Diabetes·Hedi SoussiIsabelle Dugail
Sep 24, 2015·Autophagy·Yulia HaimAssaf Rudich
Citations
Apr 1, 2017·The Journal of Endocrinology·Maayan VatarescuAssaf Rudich
Sep 21, 2018·Antioxidants & Redox Signaling·Maroua FerhatSihem Boudina
Jan 25, 2019·Adipocyte·Nir GoldsteinAssaf Rudich
Mar 7, 2018·Diabetology & Metabolic Syndrome·J KosackaN Klöting
Jul 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea ArmaniMassimiliano Caprio
Dec 25, 2019·Diabetologia·Adam J BittelW Todd Cade
Jun 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Sascha HeinitzAnke Tönjes
Sep 27, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Gulsah Kaya AksoyAygen Yılmaz
Feb 6, 2017·Protoplasma·Anna CinkajzlováMartin Haluzík
Apr 25, 2018·Nature Reviews. Endocrinology·Yingmei ZhangJun Ren
Sep 20, 2018·Current Osteoporosis Reports·Beatriz Gámez, Claire M Edwards
Sep 21, 2018·Frontiers in Psychiatry·Qing TianXiao-Qing Tang
Apr 30, 2020·Healthcare·Khurshid MattooEsam Halboub
Aug 25, 2019·Trends in Endocrinology and Metabolism : TEM·Zhiyong Cheng
Aug 2, 2020·Life Sciences·Yue LuLining Miao
Apr 3, 2021·Molecular Biology Reports·Tapan BehlSwati Chadha
Jun 5, 2021·Journal of Cellular and Molecular Medicine·Chengqian LiYujie Deng
Mar 19, 2020·Genes & Diseases·Ding YaoWu QiNan
Jul 25, 2021·International Journal of Molecular Sciences·Lowell DilworthFelix Omoruyi