Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity

International Journal of Obesity : Journal of the International Association for the Study of Obesity
N SlutskyAssaf Rudich

Abstract

Adipose tissue (AT) autophagy gene expression is elevated in human obesity, correlating with increased metabolic risk, but mechanistic links between the two remain unclear. Thus, the objective of this study was to assess whether elevated autophagy may cause AT endocrine dysfunction, emphasizing the putative role of adiponectin in fat-liver endocrine communication. We utilized a large (N=186) human AT biobank to assess clinical associations between human visceral AT autophagy genes, adiponectin and leptin, by multivariate models. A broader view of adipocytokines association with elevated autophagy was assessed using adipocytokine array. Finally, to establish causality, ex vivo studies utilizing a murine AT-hepatocyte cell line co-culture system was used. Circulating high-molecular-weight adiponectin and leptin levels were associated with human omental-AT expression of ATG5 mRNA, associations that remained significant (β=-0.197, P=0.011; β=0.267, P<0.001, respectively) in a multivariate model adjusted for age, sex, body mass index and interleukin-6 (IL-6). A similar association was observed with omental-AT LC3A mRNA levels. Bafilomycin-A1 (Baf A) pretreatment of AT explants from high-fat-fed (HFF) mice had no effect on the secret...Continue Reading

References

Nov 27, 2008·American Journal of Physiology. Endocrinology and Metabolism·Julia KovsanAssaf Rudich
Feb 18, 2009·The Journal of Clinical Investigation·Anurag Kumar SinghUrsula Seidler
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yong ZhangShengkan Jin
Jan 30, 2010·Autophagy·Scott GoldmanShengkan Jin
Jun 4, 2010·Cell Metabolism·Ling YangGökhan S Hotamisligil
Nov 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Julia KovsanAssaf Rudich
Dec 14, 2011·Biochemical and Biophysical Research Communications·Takeshi YoshizakiHiroshi Maegawa
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun
Oct 31, 2012·Obesity Facts·Nitzan MaixnerAssaf Rudich
Feb 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Hagit ShapiroAssaf Rudich
Feb 15, 2013·The New England Journal of Medicine·Augustine M K ChoiBeth Levine
Mar 13, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C E NuñezE P Araujo
Mar 31, 2015·Molecular and Cellular Endocrinology·J KosackaM Blüher

❮ Previous
Next ❯

Citations

Apr 1, 2017·The Journal of Endocrinology·Maayan VatarescuAssaf Rudich
Sep 21, 2018·Antioxidants & Redox Signaling·Maroua FerhatSihem Boudina
Jul 15, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea ArmaniMassimiliano Caprio
Jun 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Sascha HeinitzAnke Tönjes
Sep 27, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Gulsah Kaya AksoyAygen Yılmaz
Apr 25, 2018·Nature Reviews. Endocrinology·Yingmei ZhangJun Ren
Sep 20, 2018·Current Osteoporosis Reports·Beatriz Gámez, Claire M Edwards
Aug 25, 2019·Trends in Endocrinology and Metabolism : TEM·Zhiyong Cheng
Apr 3, 2021·Molecular Biology Reports·Tapan BehlSwati Chadha
Jun 5, 2021·Journal of Cellular and Molecular Medicine·Chengqian LiYujie Deng
Jul 25, 2021·International Journal of Molecular Sciences·Lowell DilworthFelix Omoruyi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.