Decreased adrenoceptor stimulation in heart failure rats reduces NGF expression by cardiac parasympathetic neurons

Autonomic Neuroscience : Basic & Clinical
Wohaib Hasan, Peter G Smith

Abstract

Postganglionic cardiac parasympathetic and sympathetic nerves are physically proximate in atrial cardiac tissue allowing reciprocal inhibition of neurotransmitter release, depending on demands from central cardiovascular centers or reflex pathways. Parasympathetic cardiac ganglion (CG) neurons synthesize and release the sympathetic neurotrophin nerve growth factor (NGF), which may serve to maintain these close connections. In this study we investigated whether NGF synthesis by CG neurons is altered in heart failure, and whether norepinephrine from sympathetic neurons promotes NGF synthesis. NGF and proNGF immunoreactivity in CG neurons in heart failure rats following chronic coronary artery ligation was investigated. NGF immunoreactivity was decreased significantly in heart failure rats compared to sham-operated animals, whereas proNGF expression was unchanged. Changes in neurochemistry of CG neurons included attenuated expression of the cholinergic marker vesicular acetylcholine transporter, and increased expression of the neuropeptide vasoactive intestinal polypeptide. To further investigate norepinephrine's role in promoting NGF synthesis, we cultured CG neurons treated with adrenergic receptor (AR) agonists. An 82% increase...Continue Reading

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Citations

May 2, 2014·Frontiers in Immunology·George Nikov ChaldakovLuigi Aloe
Oct 27, 2018·Blood·Andrés García-GarcíaSimón Méndez-Ferrer
Oct 19, 2016·Journal of Neuroscience Research·Volkan Coskun, Dawn M Lombardo
May 24, 2019·Science Translational Medicine·Katharina ScherschelChristian Meyer
Oct 10, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jhansi Dyavanapalli
Jan 20, 2021·ESC Heart Failure·Ewa Pius-Sadowska, Bogusław Machaliński

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