PMID: 8614287Jan 1, 1996Paper

Decreased affinity of K-receptor binding during reperfusion following ischaemic preconditioning in the rat heart

Life Sciences
Q XiaT M Wong

Abstract

The effects of ischaemic preconditioning with three cycles of ischaemia of 3 min and reperfusion of 5 min each cycle on ventricular fibrillation threshold (VFT) and ventricular fibrillation (VF), and binding properties of tritiated U69,593, a selective kappa opioid-receptor (k-receptor) agonist, during subsequent ischaemia and/or reperfusion were studied in the rat heart. It was found that ischaemic preconditioning significantly enhanced the VFT values during ischaemic and reperfusion. VF during the subsequent reperfusion period was also significantly reduced. The Kd of the [3H]U69,593 binding sites in the sarcolemma of the heart at 5 min of reperfusion was significantly increased following ischaemic preconditioning. The Bmax was, however, not altered after the preconditioning. The study provides evidence for the first time suggesting that the cardioprotective effects of ischaemic preconditioning may be related to a reduction in affinity of the K-receptor binding.

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Citations

Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Garrett J Gross
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·A RubajM Sieklucka-Dziuba
Apr 24, 2001·Pharmacology & Therapeutics·J E Schultz, G J Gross
May 31, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Michael G Irwin, Gordon Tin Chun Wong
Jan 25, 2003·American Journal of Physiology. Heart and Circulatory Physiology·James A ColesPaul A Iaizzo
Mar 13, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Hemangi Rawal, Bhoomika M Patel
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G Y WangT M Wong

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