Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Rodrigo Machado-VieiraSuely K N Marie

Abstract

Strong evidence implicates intracellular signaling cascades dysfunction in the pathophysiology of Bipolar Disorder (BD). Regulation of AKT/mTOR pathway is a critical signaling pathway in synaptic neurotransmission and plasticity, also modulating cell proliferation and migration. Gene expression of the AKT/mTOR pathway was assessed in 25 BD (DSM-IV-TR criteria) unmedicated depressed individuals at baseline and after 6 weeks of lithium therapy and 31 matched healthy controls. Decreases in blood AKT1 and mTOR mRNA expression, as well as in BAD/BCL-2 expression ratio were observed in short-term BD patients during depressive episodes in comparison to healthy controls. There was no significant change in the expression of AKT1, mTOR, BCL-2, BAD and NDUFA6 after lithium therapy in the total group of BD subjects. However, the changes in AKT1 expression after lithium treatment were positively correlated with depression improvement. An integrated activity within this pathway was observed at both baseline and post-treatment. The present results support an integrated AKT/mTOR signaling pathway activity in a similar fashion to the described in previous human postmortem and rodents brain studies. Overall, the results reinforce a role for AKT1...Continue Reading

References

Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·E Chalecka-Franaszek, D M Chuang
Oct 18, 2000·Biological Psychiatry·L F JarskogJ A Lieberman
Dec 17, 2010·Expert Review of Neurotherapeutics·Kenji Hashimoto
Jun 9, 2012·Acta Psychiatrica Scandinavica·M G Soeiro-de-SouzaR Machado-Vieira
Jul 10, 2012·Brain Research·Wenhua ZhengRemi Quirion
Oct 18, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Márcio Gerhardt Soeiro-de-SouzaRodrigo Machado-Vieira
Jan 16, 2013·Depression Research and Treatment·Yasuko KitagishiSatoru Matsuda
Mar 13, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lin SuoLin Lu
May 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rong-Jian LiuGeorge K Aghajanian
Sep 4, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Rodrigo Machado-VieiraCarlos A Zarate

❮ Previous
Next ❯

Citations

Jan 3, 2016·Progress in Neurobiology·Rodrigo Machado-VieiraCarlos A Zarate
Oct 31, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Innokentiy S LosenkovSvetlana A Ivanova
Aug 15, 2015·Biochemical and Biophysical Research Communications·Jintao WuJinhao Sun
Jul 26, 2016·Frontiers in Molecular Biosciences·Shima ShahjoueiRamin Zand
Jun 13, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jeverson MoreiraCynthia Marie-Claire
Feb 16, 2019·Expert Opinion on Therapeutic Targets·Devon WattsFlavio Kapczinski
Jul 5, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sophie Laguesse, Dorit Ron
Sep 4, 2019·Translational Psychiatry·A StarnawskaL Christiansen
Sep 4, 2019·Journal of Biochemical and Molecular Toxicology·Zhou LeiLi PeiFeng
Jun 4, 2019·Frontiers in Psychiatry·Nils C Gassen, Theo Rein
Sep 29, 2020·Experimental Neurology·Bruna C PieroneManuella P Kaster
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hua GanJiaxu Chen
Apr 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mimi TangRuili Dang
Dec 8, 2019·Psychiatry Research·Vincent MillischerLena Backlund
May 6, 2021·American Journal of Medical Genetics. Part a·Arianna RicciardelloAntonio M Persico
Jul 22, 2021·Depression and Anxiety·Dong YangLiping Cao

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Márcio Gerhardt Soeiro-de-SouzaRodrigo Machado-Vieira
© 2022 Meta ULC. All rights reserved