PMID: 9529094Apr 7, 1998Paper

Decreased antitoxic activities among children with clinical episodes of malaria

Infection and Immunity
P H JakobsenB M Greenwood

Abstract

Healthy Gambian children, children with clinical Plasmodium falciparum malaria, and children with asymptomatic P. falciparum infections were studied to investigate whether antitoxic activities may contribute to protection against malarial symptoms. Markers of inflammatory reactions, soluble tumor necrosis factor receptor I, and C-reactive protein were found in high concentrations in children with symptomatic P. falciparum malaria compared with levels in children with asymptomatic P. falciparum infections or in healthy children, indicating that inflammatory reactions are induced only in children with clinical symptoms. Concentrations of soluble tumor necrosis factor receptor I and C-reactive protein were associated with levels of parasitemia. We detected antitoxic activities in sera as measured by their capacity to block toxin-induced Limulus amoebocyte lysate (LAL) activation. Symptomatic children had decreased capacity to block induction of LAL activation by P. falciparum exoantigen. The decreased blocking activity was restored in the following dry season, when the children had no clinical malaria. Symptomatic children also had the highest immunoglobulin G (IgG) reactivities to conserved P. falciparum erythrocyte membrane prot...Continue Reading

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Citations

Jan 9, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B A IwalokunA Ogunledun
Feb 2, 2013·Immunologic Research·Waliza Ansar, Shyamasree Ghosh
Mar 10, 2001·Parasite Immunology·E M RileyK A Koram
Mar 28, 2008·Memórias do Instituto Oswaldo Cruz·Hossein NahrevanianMehdi Assmar
Feb 28, 2002·Redox Report : Communications in Free Radical Research·N H HuntL Sai-Kiang

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