Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy

AIDS
A IsgròF Aiuti

Abstract

Impaired haematopoiesis during HIV-1 infection may be caused by the overproduction of inflammatory cytokines by immune cells at the bone marrow level inducing Fas-mediated apoptosis of stem progenitors. In this study, we evaluated the effects of highly active antiretroviral therapy on apoptosis of CD34+ stem cells derived from the bone marrow of HIV-1-infected patients, and observed decreased Fas expression on progenitor cells, in parallel with the diminution of TNF-alpha levels and the amelioration of clonogenic parameters.

References

Jan 1, 1996·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·G Zauli, S Capitani

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Citations

Oct 11, 2005·Autoimmunity Reviews·Antonella IsgròFernando Aiuti
Aug 30, 2007·AIDS Research and Human Retroviruses·Andrew D ReddM Essex
Sep 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·David James Hooker, Catherine Louise Cherry
Jul 28, 2013·Blood·Christopher C NixonJerome A Zack
Mar 11, 2020·Frontiers in Cellular and Infection Microbiology·Tetsuo Tsukamoto
Jun 16, 2021·The Journal of Experimental Medicine·Francisco CaiadoMarkus G Manz

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