Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease.

European Urology Open Science
Simon R WalkerTarek A Bismar


Ataxia Telangiectasia Mutated (ATM) serine/threonine protein kinase is a known tumor suppressor, involved in DNA damage repair. It has prognostic and predictive therapeutic implications and is associated with aggressive prostate cancer (PCa). To investigate the prognostic value of ATM protein expression in PCa patients and assessed the combined value of ATM, ERG, and PTEN status. This study consisted of 303 patients with incidental, locally advanced, and castrate-resistant PCa by transurethral resection of the prostate (TURP). TURP samples from 303 PCa patients were assessed by immunohistochemistry (IHC for ATM, ERG, and PTEN. Individual and combined marker status were correlated with International Society of Urological Pathology Gleason grade group, overall survival (OS), and PCa-specific mortality (PCSM). Decreased ATM expression (negative/weak intensity) occurred in 164/303 (54.1%) patients, and was associated with shorter OS and higher PCSM (p = 0.015 and p = 0.001, respectively). Negative/weak ATM expression was significantly associated with PCSM with a hazard ratio of 2.09 (95% confidence interval 1.34-3.27, p = 0.001). Assessment of Combined ATM/PTEN expression showed improved prognostic power to predict OS and PCSM, ind...Continue Reading


Jun 11, 2009·Journal of the National Cancer Institute·Matthew R CooperbergPeter R Carroll
Jan 28, 2010·British Journal of Cancer·A H M ReidUNKNOWN Transatlantic Prostate Group
Mar 18, 2016·Current Opinion in Urology·Samuel D Kaffenberger, Christopher E Barbieri
Jun 4, 2016·Oncotarget·Liza C VillaruzChristopher J Bakkenist
Jul 20, 2016·The New England Journal of Medicine·Colin C PritchardPeter S Nelson
Jun 3, 2018·Current Oncology Reports·Kaveri Arora, Christopher E Barbieri
Aug 14, 2018·Journal of Cancer Research and Clinical Oncology·Tarek A BismarBruce J Trock
Oct 4, 2018·BJU International·Evan W WarnerAlexander W Wyatt
Mar 16, 2019·Cancers·Paz NombelaElena Castro
Dec 25, 2019·The Journal of Clinical Investigation·Joaquin MateoJohann S de Bono
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GillessenA G Omlin
Mar 19, 2020·Cancers·Nicholas R JetteSusan P Lees-Miller
Sep 22, 2020·The New England Journal of Medicine·Maha HussainUNKNOWN PROfound Trial Investigators

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Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

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