PMID: 8457009Mar 1, 1993Paper

Decreased availability of metabolic fuels suppresses estrous behavior in Syrian hamsters

The American Journal of Physiology
R W DickermanG N Wade

Abstract

The availability of oxidizable metabolic fuels affects reproductive physiology and behaviors in female mammals. In Syrian hamsters, 48 h of food deprivation is sufficient to suppress secretion of gonadotropins and ovarian steroids and to prevent the occurrence of ovulation and estrous behavior. These experiments attempted to determine whether the deprivation-induced suppression of lordosis is entirely due to the disruption of ovarian steroid secretion or whether there are also changes in behavioral responsiveness to estradiol and/or progesterone (P). Estrous behavior was induced in ovariectomized hamsters with sequential injections of 5 micrograms of estradiol benzoate (EB) and 200 micrograms P. Food deprivation for 48 h, either before or just after EB treatment, significantly suppressed the amount of time females spent in lordosis during a 5-min test with a sexually experienced male. Treatment with an inhibitor of glycolysis (2-deoxy-D-glucose) in combination with an inhibitor of fatty acid oxidation (methyl palmoxirate) for 48 h mimicked the effects of food deprivation and suppressed the amount of time spent in lordosis after treatment with EB+P. Given alone, neither metabolic inhibitor had an effect on lordosis. These findin...Continue Reading

Citations

Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer L TempleEmilie F Rissman
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George N Wade, Juli E Jones
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H H BaeJ Dark
Nov 6, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Maria Furman, George N Wade
Mar 2, 2011·The Journal of Reproduction and Development·Kinuyo IwataKei-ichiro Maeda
Sep 16, 2003·Medicine and Science in Sports and Exercise·George N Wade, Juli E Jones
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A HagobianBarry Braun
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J E Jones, L S Lubbers
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patricia L SeymourGeorge N Wade
Jun 5, 2003·Physiology & Behavior·Alex C KeeneEric S Corp

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