Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress

Developmental Psychobiology
Alessandra BerryFrancesca Cirulli

Abstract

Prenatal stress (PNS) is a risk factor for the development of neuropsychiatric disorders. This study was aimed at assessing, in a rodent model, changes in gene expression profiles and behavioral output as a result of PNS, during periadolescence, a critical developmental period for the onset of psychopathology. Social behavior was studied in a standardized social interaction paradigm and the expression of Brain-Derived Neurotrophic Factor (Bdnf), a marker of neuronal plasticity, and of inhibitory and excitatory mechanisms (Na(+)-K(+)-2Cl(-) and K(+)-Cl(-) cotransporters ratio, NKCC1/KCC2) was analyzed. Results indicate that PNS reduced Bdnf transcripts while increasing the NKCC1/KCC2 ratio, primarily in the hippocampus. In the prefrontal cortex, changes in Bdnf were found to be gender-dependent. These effects were accompanied by reduced levels of affiliative and investigative social behaviors. Interestingly, interaction with non-stressed subjects was able to improve sociality in PNS rats suggesting that the social environment could be exploited for therapeutic intervention.

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Citations

May 12, 2016·Expert Opinion on Therapeutic Targets·Francesca CalabreseRaffaella Molteni
Jul 15, 2017·Frontiers in Behavioral Neuroscience·Pamela PanettaFrancesca Cirulli
May 18, 2016·Neurotoxicity Research·Anna KurekBogusława Budziszewska
Jul 7, 2017·Clinical Epigenetics·Darlene A KertesConnie J Mulligan
May 1, 2020·Frontiers in Cellular Neuroscience·Tao YangHuiying Liu
Jun 6, 2020·Frontiers in Psychiatry·Monica MazzelliNadia Cattane
Oct 24, 2020·Pharmaceuticals·Alice Sanson, Marco A Riva
Feb 6, 2020·Neuroscience Research·Itsuka KamimuraTakefumi Kikusui

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