Decreased beating rate variability of spontaneously contracting cardiomyocytes after co-incubation with endotoxin

Journal of Endotoxin Research
Hendrik SchmidtUrsula Müller-Werdan

Abstract

Decreased heart rate variability (HRV) in critically ill patients indicates a poor prognosis. In heart failure patients, there is an elevated sympathetic tone, reflected by a dominance of sympathetic parameters in HRV, whereas in critically ill patients sympathetic and parasympathetic modulation of heart rate is attenuated despite increased catecholamine blood levels. Thus, autonomic dysfunction in the critically ill cannot be causally related to an impairment at the level of neural transmission, but may be due to a derangement of signal transduction at the effector cell level. On the basis of our working hypothesis that endotoxin may be involved in this blunting of effector cell response to nerval input, we studied the spontaneous beating of cardiomyocytes under the influence of endotoxin. Applying the clinically established indices of HRV to the analysis of beating rate variability (BRV) of neonatal rat cardiomyocytes in serum-free medium, a narrowing of their BRV by endotoxin is demonstrated. We propose that the narrowing of HRV in critically ill patients does not only reflect the altered input from the central or peripheral neurons, but rather a remodeling of the cardiac pacemaker cells by endotoxin and inflammatory mediators.

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Citations

Dec 4, 2012·Journal of Clinical Monitoring and Computing·Jeremy D ScheffIoannis P Androulakis
Mar 23, 2012·The Journal of Pharmacology and Experimental Therapeutics·Karthikeyan KrishnamurthyGovindasamy Ilangovan
Aug 17, 2012·American Journal of Physiology. Cell Physiology·Robert WondergemDavid L Williams
Aug 7, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Karen D FairchildJ Randall Moorman
Apr 17, 2009·Canadian Journal of Physiology and Pharmacology·Karl WerdanUrsula Müller-Werdan
Jun 6, 2009·Der Internist·K WerdanU Müller-Werdan
May 27, 2010·Der Internist·H Ebelt, K Werdan
Dec 22, 2015·Naunyn-Schmiedeberg's Archives of Pharmacology·Marwa Y SallamMahmoud M El-Mas
May 2, 2015·Clinical and Experimental Pharmacology & Physiology·Henning EbeltHarald Loppnow
May 26, 2011·Journal of Molecular and Cellular Cardiology·Udo KlöcknerMichael Gekle
Feb 1, 2014·Physiological Measurement·Roham MazloomAli R Mani

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