Decreased bioavailability of nitric oxide in aorta from ovariectomized senescent mice. Role of cyclooxygenase

Experimental Gerontology
Xavier Vidal-GómezP Medina

Abstract

This study investigates the effects of aging and/or ovariectomy on vascular reactivity to thromboxane A2 (TXA2) receptor stimulation with U46619, and the modulation by nitric oxide (NO) and cyclooxygenase (COX) in aorta from female senescence-accelerated mice (SAMP8) and from senescence resistant mice (SAMR1). Five-month-old female SAMR1 and SAMP8 were divided into three groups: sham-operated, ovariectomized and ovariectomized plus estradiol. Twenty-eight days after surgery, thoracic aortic rings were mounted for isometric recording of tension and concentration-response curves for U46619 (10(-10)-3 × 10(-7) M) were performed in the absence and in the presence of the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) and/or COX inhibitor indomethacin (10(-5)M). Vascular superoxide production was detected by dihydroethidium staining on sections of thoracic aorta. NO bioavailability in response to U46619 was suppressed by estrogen withdrawn in young and senescent mice and was restored by the administration of estradiol. In the presence of indomethacin, contractions to U46619 decreased in all groups indicating an aging- and estrogen-dependent modulation of contractile prostanoids. The simultaneous incubatio...Continue Reading

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Citations

Mar 1, 2017·Journal of Cellular and Molecular Medicine·Daniel Pérez-CremadesSusana Novella
Feb 9, 2018·International Journal of Molecular Sciences·Daniel Pérez-CremadesSusana Novella
Aug 3, 2019·The Journal of Physiology·Susana NovellaCarlos Hermenegildo
Jul 16, 2020·International Journal of Molecular Sciences·Amela Jusic On Behalf Of The Eu-CardioRNA Cost Action
Feb 26, 2016·Diseases·Cristina VassalleClara Carpeggiani
Dec 6, 2018·International Journal of Environmental Research and Public Health·Magdalena ChełchowskaTomasz M Maciejewski
Jan 24, 2019·Oxidative Medicine and Cellular Longevity·Daniel Pérez-CremadesSusana Novella
Jul 30, 2020·Prostaglandins & Other Lipid Mediators·Gulsev OzenGokce Topal
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali Mohammad Pourbagher-ShahriJurga Bernatoniene
Jul 8, 2021·Journal of Human Hypertension·Paul J ConnellyChristian Delles

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