PMID: 3770313Dec 1, 1986Paper

Decreased blood-brain barrier permeability to sodium in early experimental diabetes

Diabetes
G M KnudsenO B Paulson

Abstract

Blood-brain barrier (BBB) permeability to 24Na+, 36Cl-, and [3H]sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeability-surface area product) for Na+ in the cortex of the frontal lobes was 5.4 +/- 0.6 (10(-5) cm3 X g-1 X s-1; +/- SD) in diabetic rats compared with 7.1 +/- 1.7 in control rats. In the occipital cortex, the values were 7.6 +/- 1.5 and 9.9 +/- 1.6, respectively. In contrast, BBB permeability to Cl- and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.

Citations

Feb 1, 1993·Pharmacology & Therapeutics·W G Mayhan
Jun 1, 1994·Progress in Neurobiology·K C Wadhwani, S I Rapoport
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U GöbelW Kuschinsky
Jan 1, 1989·Journal of Neurochemistry·G M Knudsen, J Jakobsen
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G M KnudsenW Kuschinsky
Dec 15, 2015·Physiological Reports·William G MayhanDenise M Arrick
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·G E KikanoS I Harik
May 27, 2003·Diabetes·Richard D EgletonThomas P Davis
Mar 1, 1988·The American Journal of Physiology·A L McCallN B Ruderman

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