Abstract
Haemophilia patients may exhibit lower levels of bone mineral density (BMD) than the general population for a variety of reasons. We aimed to investigate decreased BMD in people with severe adult haemophilia A (PWH) living in eastern Turkey, and to evaluate the related potential risk factors. The study included 41 PWH and 40 healthy volunteers. Dual-energy x-ray absorptiometry (DXA) was used to measure the BMD. Blood tests and body mass index (BMI) were recorded. The Functional Independence Score in Hemophilia (FISH) test was used to measure functional ability status. There was a significant difference between the PWH and control groups with respect to femoral neck and total hip BMD (in g/cm2 ), but the difference for lumbar spine was not significant (P = .017, P < .001, P = .071, respectively). In PWH, patients under 50 years of age, 19.4% were found to have "lower than expected" BMD levels for their age, while 27.8% showed "low normal" levels. In PWH, osteoporosis was found in 60% of the patients over 50 and osteopenia in 20%. Vitamin D insufficiency and deficiency were present in 63.4% of the PWH, significantly higher than the control group (37.5%; P < .001). The results indicated that the decrease in BMD was significantly g...Continue Reading
References
Oct 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T P van StaaC Cooper
Nov 15, 2003·Blood·J Michael SoucieGilbert C White
Sep 11, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·F R van GenderenP J M Helders
Oct 21, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·P M PoonnooseA Srivastava
Dec 3, 2005·The Journal of Clinical Investigation·Lawrence G Raisz
Jan 11, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·T A WallnyC N Kraft
Feb 6, 2007·American Journal of Hematology·Anish P NairManish Nema
Apr 21, 2007·Blood·Sarah C DarbyMichael Williams
Sep 17, 2008·Bone·E Michael LewieckiStuart Silverman
Feb 4, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·G GerstnerA T Stopeck
Jun 3, 2009·Annals of Hematology·Olga KatsarouAnastasia Karafoulidou
Feb 2, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·M KhawajiE Berntorp
Apr 28, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesN Yoshimura
Feb 10, 2012·Thrombosis and Haemostasis·Panagiotis AnagnostisVassilia Garipidou
May 17, 2012·European Journal of Haematology·Kanjaksha Ghosh, Shrimati Shetty
Jun 8, 2012·The Journal of Clinical Endocrinology and Metabolism·Nelson B WattsUNKNOWN Endocrine Society
Aug 8, 2012·Therapeutic Advances in Musculoskeletal Disease·Robert A Adler
Jul 3, 2013·Blood Reviews·Massimo Franchini, Pier Mannuccio Mannucci
Jul 9, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S A PaschouD G Goulis
Sep 25, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·P AnagnostisD G Goulis
Nov 11, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·A J WellsP Chowdary
Jan 7, 2015·European Journal of Haematology·Mariana CanaroErik Berntorp
Aug 5, 2015·International Urology and Nephrology·Sandro C Esteves, Peter Chan
Jan 1, 2014·Bone Research·Robert A Adler
Jun 15, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·C L Sossa MeloC M Chalela
Nov 20, 2018·Best Practice & Research. Clinical Endocrinology & Metabolism·Roger Bouillon, Geert Carmeliet
Citations
Nov 10, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Domen PlutVladka Salapura
Jul 27, 2021·Drug Discovery Today·Marie CadéDominique Heymann
Aug 14, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Helen PergantouArtemis Doulgeraki
Sep 30, 2021·Thrombosis and Haemostasis·Katharina HolsteinFlorian Langer