Decreased calcium/calmodulin-dependent protein kinase II and protein kinase C activities mediate impairment of hippocampal long-term potentiation in the olfactory bulbectomized mice

Journal of Neurochemistry
Shigeki MoriguchiKohji Fukunaga

Abstract

Olfactory bulbectomized (OBX) mice showed significant impairment of learning and memory-related behaviors 14 days after olfactory bulbectomy, as measured by passive avoidance and Y-maze tasks. We here observed a large impairment of hippocampal long-term potentiation (LTP) in the OBX mice. Concomitant with decreased acetylcholinesterase expression, protein kinase C (PKC)alpha autophosphorylation and NR1(Ser-896) phosphorylation significantly decreased in the hippocampal CA1 region of OBX mice. Both PKCalpha and NR1(Ser-896) phosphorylation significantly increased following LTP in the control mice, whereas increases were not observed in OBX mice. Like PKC activities, calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation significantly decreased in the hippocampal CA1 region of OBX mice as compared with that of control mice. In addition, increased CaMKII autophosphorylation following LTP was not observed in OBX mice. Finally, the impairment of CaMKII autophosphorylation was closely associated with reduced pGluR1(Ser-831) phosphorylation, without change in synapsin I (site 3) phosphorylation in the hippocampal CA1 region of OBX mice. Taken together, in OBX mice NMDA receptor hypofunction, possibly through decre...Continue Reading

References

Jun 1, 1977·Japanese Journal of Pharmacology·T Sakurada, K Kisara
Aug 7, 1992·Brain Research·A R LumiaB Possidente
Jan 1, 1986·Biological Psychiatry·M D WarnerJ R Tinklenberg
Jun 1, 1985·The American Journal of Psychiatry·M SerbyJ Rotrosen
Oct 1, 1974·Psychological Bulletin·D P Cain
Apr 1, 1972·Physiology & Behavior·M H Sieck
Jan 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·M M Esiri, G K Wilcock
May 1, 1983·Physiology & Behavior·R D Hall, F Macrides
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·P M LledoR A Nicoll
May 10, 1995·Annals of the New York Academy of Sciences·F FonnumA R Oksengård
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Jan 1, 1997·Pharmacology & Therapeutics·J P KellyB E Leonard
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V DerkachT R Soderling
Sep 18, 1999·Science·R C Malenka, R A Nicoll
Apr 9, 2004·Methods and Findings in Experimental and Clinical Pharmacology·T TadanoK Kisara
Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Apr 2, 2005·Nature Reviews. Neuroscience·Zhengui Xia, Daniel R Storm
Jun 7, 2005·Neurochemistry International·Ana M Sánchez-Pérez, Vicente Felipo

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Citations

Jul 28, 2012·Cell Stress & Chaperones·Natalia BobkovaMichael Evgen'ev
Jun 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tairan XingDi-Yun Ruan
May 16, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kohji FukunagaFeng Han
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel A JeffreyKelsey C Martin
Jul 17, 2012·Behavioural Brain Research·Yuliya BorreRonald S Oosting
Jul 30, 2011·Trends in Biochemical Sciences·María Almena, Isabel Mérida
Oct 30, 2013·Journal of Neurochemistry·Shigeki MoriguchiKohji Fukunaga
Nov 7, 2013·The European Journal of Neuroscience·Claudia PudellAnete C Ferraz
Feb 6, 2015·Neurology Research International·Menizibeya O WelcomeVladimir A Pereverzev
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Erika AbrialLaura Lambás-Señas
Sep 11, 2012·Pharmacology, Biochemistry, and Behavior·Daniele G MachadoAna Lúcia S Rodrigues
Apr 19, 2017·Scientific Reports·Ryan D CordnerLaura C Bridgewater
Feb 18, 2018·CNS Neuroscience & Therapeutics·Xing-Guang LiangFeng Han
Dec 7, 2019·Molecular Neurobiology·Ryo InagakiKohji Fukunaga

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