PMID: 1622699Jun 1, 1992Paper

Decreased cardiac parasympathetic activity in chronic heart failure and its relation to left ventricular function

British Heart Journal
J NolanD J Ewing

Abstract

Activation of the sympathetic nervous system has been extensively studied in patients with chronic heart failure, but the parasympathetic nervous system has received relatively little attention. The objective in this study was to investigate cardiac parasympathetic activity in chronic heart failure and to explore its relation to left ventricular function. Heart rate variability was measured from 24 hour ambulatory electrocardiograms by counting the number of times each RR interval exceeded the preceding RR interval by more than 50 ms (counts). This method provided a sensitive index of cardiac parasympathetic activity. Mean (range) of counts were: waking 48 (1-275)/h, sleeping 62 (0-360)/h, and total 1310 (31-7278)/24 h. These were lower than expected, and in 26 (60%) of the 43 patients counts fell below the lower 95% confidence intervals (95% CI) for RR counts in normal subjects. A significant correlation between total 24 hour RR counts and left ventricular ejection fraction was present (r = 0.49, p less than 0.05). These results indicate that most patients with chronic heart failure have reduced heart rate variability and therefore reduced cardiac parasympathetic activity. The degree of parasympathetic dysfunction is related t...Continue Reading

References

Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
May 1, 1976·Journal of Applied Physiology·L Fagraeus, D Linnarsson
Nov 1, 1975·Journal of Applied Physiology·P G Katona, F Jih
Dec 1, 1990·American Heart Journal·G Mancia
Sep 1, 1990·Nuclear Medicine Communications·C G WathenW J Hannan
Aug 10, 1989·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial (CAST) Investigators
Sep 1, 1989·British Heart Journal·D McAreaveyD C Russell
Nov 15, 1989·The American Journal of Cardiology·G CasoloC Gori
Nov 1, 1986·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·T KurosawaR Kikawada
Mar 11, 1988·The American Journal of Medicine·T J NewmanW H Cooper
Dec 1, 1986·IEEE Transactions on Bio-medical Engineering·G A MyersD H Singer
Jan 11, 1985·The American Journal of Cardiology·W M Smith
Jul 1, 1968·The American Journal of Cardiology·J GenestR Boucher
Oct 14, 1971·The New England Journal of Medicine·D L EckbergE Braunwald
Apr 23, 1970·The New England Journal of Medicine·R Zelis, D T Mason
Jan 1, 1984·Journal of Cardiovascular Pharmacology·B J Materson, P V Caralis
Mar 25, 1983·European Journal of Pharmacology·A De JongeP A Van Zwieten
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Nov 1, 1984·British Heart Journal·J G ClelandG Gillen
Jul 1, 1984·The American Journal of Cardiology·D V UnverferthC V Leier
Apr 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D L Eckberg
Jan 1, 1982·Clinical Science·F Bellavere, D J Ewing
Jan 1, 1982·British Journal of Pharmacology·E K Potter
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D J EwingB F Clarke
Feb 9, 1935·The Journal of Physiology·A Samaan

❮ Previous
Next ❯

Citations

Feb 1, 1997·Clinical Cardiology·J Kautzner, A J Camm
Dec 1, 2007·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David K SpiererAdrienne S Zion
Feb 12, 2009·Applied Psychophysiology and Biofeedback·Kimberly S SwansonLiset Stoletniy
Feb 1, 1996·The Annals of Thoracic Surgery·S Y KimR Pifarré
Oct 1, 1994·Journal of the American College of Cardiology·M W AhmedJ J Goldberger
Mar 5, 2004·International Journal of Cardiology·Chander Mohan MittalK K Deepak
Aug 25, 2004·Survey of Ophthalmology·Doina GherghelSelim Orgül
Aug 26, 1998·The American Journal of Cardiology·I GirgisR J Myerburg
Nov 15, 1995·The American Journal of Cardiology·Y H ZhangL L Wan
May 1, 1995·Progress in Cardiovascular Diseases·I H ZuckerK P Patel
Jul 10, 2002·International Journal of Cardiology·Jiri PumprlaJames Nolan
Apr 18, 1997·International Journal of Cardiology·Z You-huaY Xian-qi
Nov 26, 2002·Journal of the American College of Cardiology·Mark T KearneyJames Nolan
Jan 1, 1997·Fundamental & Clinical Pharmacology·L Cloarec-Blanchard
Nov 1, 1995·The Journal of Small Animal Practice·C J Little, P O Julu
Jan 3, 2006·Heart·G A LanzaUNKNOWN Stratificazione Prognostica dell'Angina Instabile Study Investigators
Jan 1, 1994·British Heart Journal·M Malik, A J Camm
Feb 1, 1995·British Heart Journal·M K MandawatS M Cobbe
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Richard S T LeungT Douglas Bradley
Jan 21, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Irma BattipagliaFilippo Crea
Aug 10, 2000·Journal of Veterinary Internal Medicine·M MiyamotoR L Hamlin
Apr 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J P SpiersD W Harron
Jul 10, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Thomas Klingenheben, Stefan H Hohnloser
Nov 13, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·René van LienEco J C de Geus
Dec 7, 2007·The Canadian Journal of Cardiology·Richard J SheppardMichel White

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