Decreased CD161+CD8+ T cells in the peripheral blood of patients suffering from rheumatic diseases

Rheumatology
A MitsuoH Hashimoto

Abstract

Although it has been reported that the numbers of both CD4(-)CD8(-) and CD4(+) natural killer T (NKT) cells are selectively decreased in the peripheral blood of patients with rheumatic diseases, there have been no reports concerning a novel subpopulation of CD8(+) NKT cells. To examine whether CD161(+)CD8(+) T cells, which are closely related to CD8(+) NKT cells, are also decreased in patients with rheumatic diseases, we have investigated the expression of CD161, together with that of CD28, CD25 and CD62L, on T cells in the peripheral blood of these patients. The rheumatic diseases evaluated in this study were systemic lupus erythematosus (SLE) (n= 54), mixed connective-tissue disease (MCTD) (n= 15), systemic sclerosis (SSc) (n= 14), polymyositis/dermatomyositis (PM/DM) (n= 13) and rheumatoid arthritis (RA) (n= 24). Healthy donors were examined as controls (n= 18). The expression of CD161, CD28, CD25 and CD62L on T cells was analysed by flow cytometry. Both the frequency of CD161 expression on CD8(+) cells and the absolute number of CD161(+)CD8(+) cells were significantly decreased in patients with SLE, MCTD, SSc and PM/DM. Only the absolute number of CD161(+)CD8(+) T cells was significantly decreased in RA. CD161 expression on...Continue Reading

Citations

Jan 11, 2011·Brain : a Journal of Neurology·Viviana AnnibaliMarco Salvetti
Feb 18, 2010·European Journal of Medical Research·Thilo GambichlerA Kreuter
Apr 26, 2012·Arthritis Research & Therapy·Lara Bossini-CastilloUNKNOWN Spanish Scleroderma Group
Oct 3, 2012·PloS One·James V DunneKevin J Keen
Jul 5, 2012·Clinical & Developmental Immunology·Yi-Ping ChuangHuey-Kang Sytwu
Aug 21, 2009·Current Rheumatology Reports·Ann M Reed, Floranne Ernste
Jan 29, 2008·Seminars in Arthritis and Rheumatism·Y Stephanie GuM Eric Gershwin
Sep 18, 2009·Annals of the New York Academy of Sciences·Luisa GabrielNicola J Rogers
Apr 24, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Nicholas A GherardinPaul J Neeson
Apr 21, 2010·Muscle & Nerve·Sahil Khanna, Ann M Reed
Dec 30, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sung-Eun LeeChang-Ki Min
Sep 6, 2007·Arthritis Research & Therapy·Dirk M WuttgeAnita Akesson
Jun 15, 2013·Journal of the Neurological Sciences·Luana BenedettiChiara Briani
Jan 14, 2012·PloS One·Isidoro González-ÁlvaroRosario García-Vicuña
Jan 5, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne WillingManuel A Friese
Jan 10, 2017·Frontiers in Immunology·María Luisa Pita-LópezRafael Solana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.