Decreased CD4+ lymphocytes and innate immune responses in adults with previous extrapulmonary tuberculosis

The Journal of Allergy and Clinical Immunology
Paulo R Z AntasTimothy R Sterling

Abstract

CD4+ lymphocytes control Mycobacterium tuberculosis infection through cytokine-mediated macrophage activation. Extrapulmonary tuberculosis is presumably a marker of immunodeficiency, but cytokine responses have not been well studied in such patients. Assess immune defects in persons with previous extrapulmonary tuberculosis. In vitro cytokine responses of PBMCs from HIV-seronegative adults with previous extrapulmonary tuberculosis (n = 10) were compared with responses from persons with previous pulmonary tuberculosis (n = 24) and latent M tuberculosis infection (n = 30) in a case-control study. Patients and controls did not differ according to age, sex, race, or monocytes. The median time between tuberculosis diagnosis and study entry was 72 and 122 weeks in extrapulmonary and pulmonary patients, respectively (P = .2). Median CD4+ counts were 660, 814, and 974 lymphocytes/mm3 in extrapulmonary, pulmonary, and latently infected patients, respectively (P = .03). At 48 hours, median unstimulated cytokine levels were uniformly lower in extrapulmonary patients than both sets of controls. These differences persisted after controlling for CD4+ count by linear regression analysis. Despite lower unstimulated levels, median TNF-alpha res...Continue Reading

Citations

Nov 1, 2011·Clinical and Vaccine Immunology : CVI·Alexandre S de AlmeidaSpyros A Kalams
Jan 26, 2010·BMC Infectious Diseases·Christina T FiskeTimothy R Sterling
Mar 1, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Paulo AntasTimothy Sterling
Mar 2, 2016·Epidemiology and Infection·M J MageeR R Kempker
Jun 26, 2007·The Journal of Allergy and Clinical Immunology·Javier Chinen, William T Shearer
Dec 7, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Roberto Manfredi, Leonardo Calza
Jan 12, 2013·Tuberculosis·Brenda SáenzGraciela Cárdenas
Nov 28, 2013·Tuberculosis·Moises A HuamanChristina T Fiske

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