Decreased central serotonin function in hypothyroidism

European Journal of Pharmacology
A Vaccari

Abstract

Male rats born of mothers kept on an iodide-free diet from day 15 of pregnancy up to day 4 post-delivery, were rendered hypothyroid by a daily s.c. injection of methimazole, 20-25 mg/kg from day 1 up to day 30 of age. Two days after the last injection, euthyroid and hypothyroid rats were given 220 mg/kg i.p. of L-5-hydroxytryptophan (5-HTP). The resulting behavioral syndrome was much less intense in hypothyroids, compared to euthyroids, thus suggesting a state of serotonergic hypoactivity.

Citations

Jan 1, 1988·Psychopharmacology·J MassolP Simon
Nov 11, 1983·European Journal of Pharmacology·A VaccariP S Timiras
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·P MartinA J Puech
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A C GranholmA Seiger
Jul 13, 2007·Anais Da Academia Brasileira De Ciências·Luís C Reis
Apr 2, 2004·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Saint-Clair Bahls, Gisah Amaral de Carvalho

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