Decreased cerebellar posterior vermis size in fragile X syndrome: correlation with neurocognitive performance

Neurology
S H MostofskyA L Reiss

Abstract

We examined whether posterior vermis size is smaller in individuals with fragile X syndrome (fra X) than in control subjects and whether this decreased size is associated with cognitive performance. Cognitive and behavioral dysfunctions have been identified in fra X; however, underlying neuropathogenic mechanisms remain unclear. MRI was used to investigate the posterior fossa in 32 males with fra X, 28 males with other causes of cognitive disability (CD), and 38 males with normal development (ND) as well as and in 37 females with fra X and 53 female control subjects. Among females with fra X, neurocognitive correlates of posterior vermis size were examined. Posterior vermis size (cross-sectional area) in males with fra X was significantly smaller compared with CD and ND groups, particularly when corrected for intracranial area. Posterior vermis size corrected for intracranial area was significantly smaller in females with fra X compared with control subjects. Compared with males with fra X and non-fra X control subjects, posterior vermis size in females with fra X was intermediate. After statistically removing the effect of mean parental IQ, posterior vermis size predicted a significant proportion of the variance (10 to 23%) of...Continue Reading

References

Jan 1, 1992·Journal of the American Academy of Child and Adolescent Psychiatry·R L Cohen
Feb 1, 1992·Brain : a Journal of Neurology·J G OjemannE Lettich
Jul 1, 1991·Behavioural Brain Research·S E Hall, D E Mitchell
Sep 1, 1990·Brain and Cognition·A W YoungF Newcombe
Jan 1, 1986·American Journal of Medical Genetics·J M Opitz
Sep 1, 1995·Nature Genetics·J Burn, T Strachan
Mar 13, 1995·American Journal of Medical Genetics·C McElveenY Lacassie
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·C A Ryan
Jan 1, 1993·Nature Genetics·D H Hamer
Jul 12, 1996·American Journal of Medical Genetics·L TranebjaergP Willems
Jul 1, 1994·Science

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Citations

Jun 3, 2009·Archives of General Psychiatry·Simona SpinelliElliot Stein
Sep 12, 2000·Mental Retardation and Developmental Disabilities Research Reviews·A L ReissM Haberecht
Mar 14, 2002·Developmental Psychobiology·James D ChurchillWilliam T Greenough
Jul 12, 2002·Microscopy Research and Technique·Wendy R KatesWalter E Kaufmann
Dec 24, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Michael S SalmanMaureen Dennis
Jul 13, 2011·Journal of Neurology·Anne Gallagher, Brian Hallahan
Mar 12, 2009·Neurogenetics·Shelli R KeslerAllan L Reiss
Dec 6, 2008·The Cerebellum·Maja Steinlin
Jul 21, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Lulu W WangRandi J Hagerman
May 7, 2013·Research in Developmental Disabilities·Deny MenghiniLaura Petrosini
Feb 13, 2001·Biological Psychiatry·T IchimiyaY Sudo
Oct 2, 2001·Journal of Psychiatric Research·J E SchmittA L Reiss
May 12, 2001·Neurotoxicology and Teratology·R R HolsonJ Adams
Apr 17, 2002·Schizophrenia Research·Gaku OkugawaIngrid Agartz
Jun 3, 2009·Behavioral Neuroscience·Michael J Tobia, Diana S Woodruff-Pak
Apr 27, 2011·Behavioral Neuroscience·Kimberly S CastenRebecca D Burwell
Dec 6, 2012·European Journal of Human Genetics : EJHG·Inge HeulensPeter Hammond
Mar 11, 2000·Journal of Intellectual Disability Research : JIDR·A VerriA Federico
Nov 9, 2005·Médecine sciences : M/S·Pierre BilluartSimone Gilgenkrantz
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Fumiko HoeftAllan L Reiss
Oct 12, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·D G MurphyS I Rapoport
Jul 5, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·M MoldavskyT Lerman-Sagie
Aug 2, 2005·Neuroreport·Elizabeth D O'HareElizabeth R Sowell
Jul 20, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·K M CornishR Hagerman
Jun 8, 2002·Annual Review of Neuroscience·William T O'Donnell, Stephen T Warren
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·V MenonA L Reiss
Dec 10, 2013·The Cerebellum·Peter MariënWolfram Ziegler
Apr 28, 2011·Journal of Developmental and Behavioral Pediatrics : JDBP·Frances A ConnersEdward C Merrill
Jan 3, 2001·Brain : a Journal of Neurology·M AllinR M Murray
Nov 18, 2010·Neurologia i neurochirurgia polska·Małgorzata Lisik, Aleksander Sieroń
Nov 9, 2015·World Journal of Pediatrics : WJP·Shi-Yu LuoRan-Hui Duan
Nov 11, 2011·Brain and Cognition·Nagwa A MeguidAlan C Evans
Aug 2, 2011·Psychiatry Research·Deanna GreensteinJudith Rapoport
Feb 5, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jeremy D CohenAllan L Reiss
Nov 6, 2009·Journal of Neurodevelopmental Disorders·Scott S HallAllan L Reiss

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