Decreased circulating endothelial progenitor cell levels and function in patients with nonalcoholic fatty liver disease.

PloS One
Chia-Hung ChiangShing-Jong Lin

Abstract

Nonalcoholic fatty liver disease (NAFLD) is associated with advanced atherosclerosis and a higher risk of cardiovascular disease. Increasing evidence suggests that injured endothelial monolayer is regenerated by circulating bone marrow derived-endothelial progenitor cells (EPCs), and levels of circulating EPCs reflect vascular repair capacity. However, the relation between NAFLD and EPC remains unclear. Here, we tested the hypothesis that patients with nonalcoholic fatty liver disease (NAFLD) might have decreased endothelial progenitor cell (EPC) levels and attenuated EPC function. A total of 312 consecutive patients undergoing elective coronary angiography because of suspected coronary artery disease were screened and received examinations of abdominal ultrasonography between July 2009 and November 2010. Finally, 34 patients with an ultrasonographic diagnosis of NAFLD, and 68 age- and sex-matched controls without NAFLD were enrolled. Flow cytometry with quantification of EPC markers (defined as CD34(+), CD34(+)KDR(+), and CD34(+)KDR(+)CD133(+)) in peripheral blood samples was used to assess circulating EPC numbers. The adhesive function, and migration, and tube formation capacities of EPCs were also determined in NAFLD patient...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jun 27, 1998·Cardiovascular Drugs and Therapy·M C Verhaar, T J Rabelink
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·H Drexler, B Hornig
Feb 14, 2003·The New England Journal of Medicine·Jonathan M HillToren Finkel
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Jul 16, 2003·Circulation·Frederick M RauscherDoris A Taylor
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Angel BreaEmilio Ros
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrea GalliAlessandro Casini
May 12, 2005·Journal of Hepatology·Dominique Pessayre, Bernard Fromenty
Jun 28, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola VillanovaGiulio Marchesini
Jul 12, 2005·Journal of Hepatology·Jian-Gao FanShi-Yao Chen
Aug 13, 2005·World Journal of Gastroenterology : WJG·Yu-Cheng LinJong-Dar Chen
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·L A Adams, P Angulo
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Jul 29, 2006·Stroke; a Journal of Cerebral Circulation·Gian Paolo FadiniSaula Vigili de Kreutzenberg
Feb 14, 2007·Journal of Gastroenterology and Hepatology·Giovanni TarantinoAdriano Arena
Aug 11, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna Kotronen, Hannele Yki-Järvinen
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Seyed Amir MirbagheriMehdi Abouzari
Aug 30, 2007·Internal Medicine Journal·O SenturkA Celebi
Feb 6, 2008·Atherosclerosis·Gian Paolo FadiniAngelo Avogaro
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Apr 3, 2008·Internal Medicine Journal·R K Schindhelm, M Diamant
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Jul 17, 2010·American Journal of Hypertension·Charalambos VlachopoulosChristodoulos Stefanadis
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Oct 21, 2010·Seminars in Liver Disease·Ariel E Feldstein

❮ Previous
Next ❯

Citations

May 19, 2012·Current Opinion in Cardiology·Lokpal S BhatiaChristopher D Byrne
Nov 12, 2013·Experimental Gerontology·Gianluigi MazzoccoliManlio Vinciguerra
Jun 24, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hak Soo Kim, Yong Kyun Cho
Nov 21, 2019·Alcoholism, Clinical and Experimental Research·Rashi SehgalNirupma Trehanpati
Dec 30, 2014·World Journal of Hepatology·Masayoshi TakeuchiSho-Ichi Yamagishi
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Slava BergerLena Lavie
Oct 8, 2016·Digestive Diseases and Sciences·Tracey G SimonRobert Giugliano
Apr 18, 2021·Metabolism: Clinical and Experimental·Emir MuzurovićChristos Mantzoros
May 1, 2021·Journal of Clinical Medicine·Mohammad Said RamadanRosa Zampino
Jul 3, 2021·International Journal of Molecular Sciences·Anne-Christine PeyterCatherine Yzydorczyk
Jun 17, 2021·Tobacco Induced Diseases·Kumboyono KumboyonoTitin Andri Wihastuti
Nov 30, 2020·Archives of Biochemistry and Biophysics·Ariel SassonStephen J Peterson

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
flow cytometry
density gradient centrifugation
Assay

Software Mentioned

SPSS
Image
Pro Plus

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.