Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity

Dermatology Research and Practice
Doaa Salah Hegab, Mohamed Attia Saad Attia

Abstract

Background. Vitiligo is an acquired depigmentary skin disorder resulting from autoimmune destruction of melanocytes. Regulatory T cells (Tregs), specifically CD4(+)CD25(+) and Forkhead box P3(+) (FoxP3(+)) Tregs, acquired notable attention because of their role in a variety of autoimmune pathologies. Dysregulation of Tregs may be one of the factors that can break tolerance to melanocyte self-antigens and contribute to vitiligo pathogenesis. Methods. In order to sustain the role of Tregs in pathogenesis and disease activity of vitiligo, surface markers for CD4(+)CD25(+) and FoxP3(+) peripheral Tregs were evaluated by flow cytometry in 80 Egyptian patients with nonsegmental vitiligo in addition to 60 healthy control subjects and correlated with clinical findings. Results. Vitiligo patients had significantly decreased numbers of both peripheral CD4(+)CD25(+) and FoxP3(+) T cells compared to control subjects (11.49%  ± 8.58% of CD4(+) T cells versus 21.20%  ± 3.08%, and 1.09%  ± 0.96% versus 1.44%  ± 0.24%, resp., P < 0.05 for both). Peripheral numbers of CD4(+)CD25(+) and FoxP3(+) Tregs correlated negatively with VIDA score. Conclusion. Treg depletion with impaired immune downregulatory function might play a key role in the autoim...Continue Reading

References

Jul 3, 2002·Nature Reviews. Immunology·Ethan M Shevach
Aug 7, 2002·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
May 1, 2004·The Journal of Experimental Medicine·Martin A KriegelHanns-Martin Lorenz
Oct 7, 2004·International Immunology·Haruhiko YagiShimon Sakaguchi
Mar 25, 2005·The British Journal of Dermatology·K E BirchM H A Rustin
May 20, 2005·European Journal of Immunology·Giovanna RoncadorAlison H Banham
Feb 21, 2008·Nature Immunology·Qizhi Tang, Jeffrey A Bluestone
Feb 24, 2010·Pigment Cell & Melanoma Research·Jared KlarquistI Caroline Le Poole
Jul 13, 2011·Dermatology Research and Practice·Tamihiro Kawakami, Takashi Hashimoto
Aug 2, 2011·Dermatology Research and Practice·Naoki OisoAkira Kawada
Oct 12, 2011·Pigment Cell & Melanoma Research·M Ben AhmedH Louzir
Apr 24, 2013·European Journal of Dermatology : EJD·Antonio RichettaStefano Calvieri
May 18, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manoj Kumar TembhreSomesh Gupta
Jan 1, 2014·Photodermatology, Photoimmunology & Photomedicine·Nayera H MoftahNancy A M Ali
Mar 13, 2014·Experimental Dermatology·Rehab A HegazyLaila A Rashed
Jan 31, 2015·The Journal of Investigative Dermatology·Jonathan M EbyI Caroline Le Poole
Mar 20, 2015·World Journal of Clinical Cases·Ghada F MohammedMohammed Saleh Al-Dhubaibi
Apr 18, 2015·Expert Opinion on Therapeutic Targets·Jeffrey A BluestoneDaqi Xu
Oct 13, 2015·Autoimmune Diseases·Ana Cláudia Guimarães AbreuMariana Gontijo Ramos

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Citations

Nov 18, 2020·Medicinal Research Reviews·Jianru ChenChunying Li
Dec 19, 2020·Frontiers in Immunology·Zhussipbek MukhatayevI Caroline Le Poole
Mar 20, 2021·Frontiers in Immunology·Erica L Katz, John E Harris
Dec 24, 2018·The Journal of Allergy and Clinical Immunology·Tali CzarnowickiEmma Guttman-Yassky

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Methods Mentioned

BETA
flow cytometry
Flow Cytometric
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS
CellQuest Pro

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