Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
W TuJi-Zong Zhao

Abstract

Irisin was discovered as a PGC-1a-activated messenger of myocytes that links sedentary lifestyle, obesity, and diabetes. In this study, we investigated the short-term prognostic value of early measurement of irisin concentration in 1530 Han Chinese patients with acute ischemic stroke (AIS) from three stroke centers. The subjects were the first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Clinical information and stroke severity were collected at admission. Neurological evaluations were conducted at the 6-month follow-up. Serum levels of irisin, National Institutes of Health Stroke Scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 6 months. Multivariate analyses were performed using logistic regression models. During follow-up, a poor functional outcome was found in 588 patients (38.4%; 95% confidence interval (CI), 36.0-40.9%), and 325 patients died (21.2%; 95% CI, 19.2-23.3%). The stroke patients included in the study were divided into four groups according to irisin quartiles (first is the lowest level). Poor outcome across the irisin quartiles ranged from 54.5% (first ...Continue Reading

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Citations

May 28, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken ChenDachun Yang
Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Aug 14, 2020·Nutritional Neuroscience·Ping ZhangJinggui Song
Aug 16, 2019·Cardiovascular Diabetology·Zengliang WangShuo Wang
Feb 26, 2019·Therapeutic Hypothermia and Temperature Management·Travis C Jackson, Patrick M Kochanek
Apr 11, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Meng ZhangXudong Pan
May 1, 2021·International Journal of Molecular Sciences·Lidia WlodarczykElzbieta Miller
Jul 15, 2021·Oxidative Medicine and Cellular Longevity·Yuan ZhouXiang Fan
Jul 12, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sahel TaravatiGoksel Tanigor

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS
ROCR
GraphPad Prism

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