Decreased copy number of mitochondrial DNA in Ewing's sarcoma

Clinica Chimica Acta; International Journal of Clinical Chemistry
Man YuQing-Hua Zou

Abstract

Somatic mutations and germline variations in mitochondrial DNA (mtDNA) have been widely detected in a range of human malignancies including Ewing's sarcoma (EWS). However, it still remains unknown whether quantitative alterations in mtDNA level occur during the initiation and/or progression of EWS. To test this possibility, we determined mtDNA copy number from 17 cases of EWS tumor tissues and 5 normal bone tissue samples using a quantitative real-time PCR assay. Our results showed that the average mtDNA content was significantly reduced in cancerous specimens as compared to that in normal bone controls. mtDNA copy number was statistically associated with tumor metastasis. There was an over 2-fold decrease in tumors with metastasis than in low-grade ones without metastasis. In addition, change in mtDNA content was related to somatic mutations in the D-loop control region. Tumors harboring D-loop mutations, at the polycytidine stretch between nucleotide positions 303 and 309 or close to the replication origin sites of the heavy strand, exhibited significantly lowered mtDNA levels in comparison with those without D-loop alterations. The mtDNA content reduction may be an important genetic event in the carcinogenesis of EWS. This s...Continue Reading

References

Sep 1, 1988·Journal of Cellular Physiology·E D Robin, R Wong
Jan 8, 1998·Proceedings of the Society for Experimental Biology and Medicine·Y H Wei
Aug 22, 2000·Cancer·E de AlavaM Ladanyi
Jan 15, 2003·Experimental Physiology·Hans HoppelerMartin Flück
Jan 29, 2003·Experimental Physiology·Joachim M WeitzelHans J Seitz
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael M KimJoseph A Califano
May 10, 2005·DNA Repair·Bennett Van HoutenJanine H Santos
May 14, 2005·Genes, Chromosomes & Cancer·Chew-Wun WuHsin-Chen Lee
Jun 21, 2005·Annals of the New York Academy of Sciences·Yue WangPhillip Nagley
Aug 13, 2005·Advances in Anatomic Pathology·Joseph D Khoury
Nov 24, 2005·Nature Reviews. Genetics·Xin Jie Chen, Ronald A Butow
Feb 16, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S YamadaA Nakao
Mar 29, 2006·Genes, Chromosomes & Cancer·Ling-Ming TsengHsin-Chen Lee
Jan 26, 2007·Cancer Letters·Nicolò Riggi, Ivan Stamenkovic
May 7, 2008·The American Journal of Pathology·Gerald S Shadel
Jul 31, 2008·Journal of the National Cancer Institute·Jinliang XingXifeng Wu
Mar 24, 2009·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Laura L Clay MontierYidong Bai
Apr 1, 2009·International Journal of Molecular Sciences·Hsin-Chen Lee, Yau-Huei Wei
May 6, 2009·Biochimica Et Biophysica Acta·Maria A LebedevaGerald S Shadel
May 8, 2009·Current Opinion in Pediatrics·Travis HeareShelley Dell'Orfano
May 15, 2009·Journal of Carcinogenesis·Mariola KulawiecKeshav K Singh
Jul 18, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Man YuRuifang Niu
Aug 5, 2009·Genes & Development·Douglas C Wallace, Weiwei Fan
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Chen-Sung LinYau-Huei Wei
Sep 10, 2009·Cancer Research·José Luis OrdóñezJuan Madoz-Gúrpide
Sep 30, 2009·Biochemical and Biophysical Research Communications·Man YuYanwei Xi
Oct 1, 2009·Mitochondrion·Jie ShenHua Zhao

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Citations

Mar 26, 2011·Sarcoma·Mona S JahromiJoshua D Schiffman
Apr 15, 2014·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Inna N ShokolenkoMikhail F Alexeyev
Feb 24, 2011·Expert Review of Anticancer Therapy·Danielle G SmithSusan A Burchill
Apr 9, 2015·Annals of Human Genetics·Katarzyna LinkowskaTomasz Grzybowski
Dec 18, 2019·BMC Cancer·Tarek ZaidiehQian An
Nov 24, 2016·International Journal of Oncology·Masayuki MorishitaToshihiro Akisue
Apr 16, 2016·Head & Neck·Daisuke TakedaTakahide Komori
Dec 15, 2020·FEBS Letters·Roberta FilogranaNils-Göran Larsson

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