PMID: 2108083Apr 1, 1990Paper

Decreased cytosolic calcium and prostaglandin synthesis in prehypertensive rats

Hypertension
P A CravenF R Derubertis

Abstract

The capacity of cultured renal medullary interstitial cells derived from Dahl salt-sensitive and salt-resistant rats to synthesize prostaglandin E2 (PGE2) was compared. Basal and arginine vasopressin (AVP)-induced PGE2 production by interstitial cells from salt-resistant rats was fourfold to fivefold higher than corresponding values of those from the salt-sensitive rats. Similarly, basal and AVP-responsive release of [3H]arachidonate were twofold higher by interstitial cells from salt-resistant compared with salt-sensitive rats. Differences in PGE2 production were abolished by the calcium inophore A23187 or the addition of exogenous arachidonate. The latter findings suggested a role for altered availability of endogenous arachidonate, possibly mediated by reduced calcium-responsive lipase activity. Basal and AVP-induced increases in cytosolic free calcium concentration, assessed by the aequorin method, were significantly lower in interstitial cells from salt-sensitive versus salt-resistant rats, further supporting a possible role for altered cellular calcium homeostasis. Studies of the potential contribution of various phospholipases and of triglyceride lipase to the release of arachidonate for PGE2 synthesis in interstitial ce...Continue Reading

References

Oct 29, 1979·Biochemical and Biophysical Research Communications·M L BlankE E Muirhead
Oct 1, 1985·Physiological Reviews·Y V Postnov, S N Orlov
Feb 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C MichelO E Brodde
Feb 15, 1988·Experientia·A RemmalP Marche
Apr 1, 1988·The American Journal of the Medical Sciences·E H Blaine
Aug 1, 1986·The American Journal of Physiology·A B BorleK W Snowdowne
Oct 1, 1986·Agents and Actions·J Morley
Apr 1, 1988·The American Journal of the Medical Sciences·D Susić
Apr 1, 1988·The American Journal of the Medical Sciences·M Mistry, A Nasjletti
Apr 1, 1986·Kidney International·M G BianchettiC Ferrier
Feb 15, 1987·Analytical Biochemistry·P P Van Veldhoven, G P Mannaerts
Dec 15, 1986·Biochemical and Biophysical Research Communications·K TakaoriT Takeda
Jan 1, 1986·American Journal of Nephrology·C LechiA Lechi
Apr 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M C Smith, M J Dunn
Nov 1, 1985·The American Journal of the Medical Sciences·C Limas, C J Limas
Nov 1, 1984·The American Journal of Physiology·K W Snowdowne, A B Borle
Oct 1, 1984·Journal of Hypertension·B F Robinson
Dec 1, 1981·Clinical Science·E E MuirheadW L Brosius
Feb 1, 1960·The Journal of Clinical Investigation·E E MUIRHEADF JONES

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Citations

Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J G Mongeau
Feb 27, 2013·Nature Reviews. Nephrology·Lise BankirEberhard Ritz
Mar 1, 1991·Hypertension·P A Craven, F R DeRubertis
Mar 13, 2015·American Journal of Physiology. Renal Physiology·Yu LiuRajeev Rohatgi

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