Abstract
The pathophysiology of diastolic dysfunction is complex, but can be simply described as impaired LV myocardial relaxation and/or increased LV stiffness. The objective of this study is to clarify true normal left ventricular (LV) diastolic function and early stage of diastolic dysfunction before relaxation abnormality develops in patients with normal LV diastolic function using simple diastolic wall strain (DWS) in South Korea. DWS which is a non-invasive, load-independent, and reproducible estimator of LV stiffness using two-dimensional echocardiography using the difference between posterior wall thickness in systole and diastole to approximate LV stiffness. A total of 349 consecutive patients with normal LV diastolic function by echocardiography were enrolled. According to DWS, patients were divided into two groups: high DWS (≥median 175) vs. low DWS (<median 174). Patients with low DWS were more obese and showed higher blood pressure, and had more prevalent hypertension and hyperlipidemia. In addition, those with low DWS had higher LV end-systolic volume, LV mass index, E/E' and lower ejection fraction and E' velocity. Among them, higher LVESV and LVMI were independently associated with low DWS. These data suggests that simpl...Continue Reading
References
Apr 1, 1977·Circulation·R B Devereux, N Reichek
Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerS Feinstein
May 11, 1999·Circulation·J BlacherG M London
Jan 19, 2002·Hypertension·Pierre BoutouyrieStéphane Laurent
Oct 16, 2002·Circulation·Kennedy CruickshankRay G Gosling
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Stéphane LaurentPierre Boutouyrie
Jun 22, 2005·Circulation·Kim Sutton-TyrrellUNKNOWN Health ABC Study
Dec 27, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangUNKNOWN European Association of Echocardiography
Feb 8, 2006·Circulation·Tine Willum-HansenJørgen Jeppesen
Mar 7, 2006·Journal of the American College of Cardiology·Teresa S M TsangJames B Seward
Jul 25, 2007·Circulation·Mario KasnerCarsten Tschöpe
Nov 11, 2008·European Heart Journal·Carly JenkinsThomas H Marwick
Feb 3, 2009·Journal of Cardiac Failure·Yasuharu TakedaKazuhiro Yamamoto
Mar 31, 2010·Heart·Daniel D Correa de SaHorng H Chen
Jun 10, 2010·European Heart Journal·UNKNOWN Reference Values for Arterial Stiffness' Collaboration
Nov 23, 2011·Circulation·James E Udelson
May 31, 2012·European Heart Journal·Tomohito OhtaniMargaret M Redfield
Aug 17, 2012·Current Opinion in Nephrology and Hypertension·Laurie A Tomlinson
Nov 7, 2012·Cerebrovascular Diseases·P-J TouboulK S Woo
Sep 1, 2014·Journal of Echocardiography·Masashi SuzueShoji Kagami
Sep 1, 2014·Journal of Echocardiography·Tsutomu TakagiJunichi Yoshikawa
Citations
Apr 27, 2016·Heart and Vessels·Yuko SoyamaTohru Masuyama
Oct 8, 2016·Clinical Cardiology·Shunsuke UetakeWataru Shimizu
Mar 2, 2017·Echocardiography·Edinrin ObasareGregg S Pressman
Mar 23, 2017·International Heart Journal·Masatoshi MinamisawaUichi Ikeda
Dec 30, 2017·BMC Cardiovascular Disorders·Jaehuk ChoiNamho Lee
Mar 7, 2020·Circulation·Ambarish PandeyUNKNOWN Look AHEAD Research Group