Decreased diffusivity in the caudate nucleus of presymptomatic huntington disease gene carriers: which explanation?

AJNR. American Journal of Neuroradiology
M L MandelliM Grisoli

Abstract

The neostriatum is known to be affected in HD. In this work, our aim was to determine whether microstructural and volumetric alterations occur in the neostriatum of presymptomatic HD gene carriers and in patients with early-stage HD. We studied a group of 15 presymptomatic gene carriers who were far from the estimated symptom onset (16% probability of developing the disease within 5 years), a group of 9 patients with early symptomatic HD, and 2 groups of age-matched controls. Volumetric MR imaging and DWIs were acquired, and statistical analyses were performed on the volumes of the caudate nucleus and putamen and on the corresponding MD measurements. Neostriatal volumes were significantly smaller in both presymptomatic HD gene carriers and symptomatic patients with respect to controls. However, whereas the diffusivity in the caudate nucleus was increased in the symptomatic patients, it was decreased in the presymptomatic gene carriers. Altered diffusivity and reduced volume of the caudate nucleus in presymptomatic HD gene carriers indicate that the neostriatum is affected well before the onset of symptoms. The observed initial decrease and subsequent increase of MD might be related to the combined effect of increased oligodendr...Continue Reading

References

Sep 1, 1992·AJR. American Journal of Roentgenology·D Le BihanN Patronas
Nov 11, 1991·Journal of Neuropathology and Experimental Neurology·R H MyersE D Bird
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Mar 1, 1994·Journal of Magnetic Resonance. Series B·P J BasserD LeBihan
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·S D Taylor-RobinsonD J Brooks
Jul 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·C M HawD Kohen
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E H AylwardC A Ross
Mar 18, 2004·Clinical Genetics·D R LangbehnUNKNOWN International Huntington's Disease Collaborative Group
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·S CaladoK Mansinho
Mar 30, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiGregor K Wenning
Jun 7, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·H Diana RosasDavid H Salat
Mar 14, 2007·Brain Research Bulletin·Elizabeth H Aylward
Jul 29, 2008·Psychiatry Research·Jeffrey Chee Leong LooiLars-Olof Wahlund
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Günther Deuschl

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Citations

Jul 3, 2013·Brain Imaging and Behavior·Penny A MacDonaldSherif Karama
May 24, 2012·Brain Structure & Function·Bjørnar T AntonsenTrygve B Leergaard
Feb 3, 2015·Human Brain Mapping·Marianne J U NovakSarah J Tabrizi
Apr 29, 2015·Magnetic Resonance Imaging·Joseph GoveasMarco Giannelli
Dec 19, 2015·The British Journal of Psychiatry : the Journal of Mental Science·Juan F Domínguez DNellie Georgiou-Karistianis
Feb 6, 2020·Current Medical Imaging Reviews·Rodolfo Gabriel Gatto, Carina Weissmann
Oct 10, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Carlos Estevez-FragaSarah Gregory

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