Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia

Archives of General Psychiatry
Tetsuya SuharaLars Farde

Abstract

The clinical efficacy of dopamine D2 receptor antagonism on the psychotic symptoms of schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not been able to detect significant changes in striatal D2 receptors in schizophrenia. On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia. Eleven drug-naive male patients with schizophrenia were examined with positron emission tomography using carbon 11-labeled FLB 457. Symptoms were assessed using the Brief Psychiatric Rating Scale. Eighteen healthy controls were used for comparison. Region-of-interest analysis was performed using the reference tissue method, and binding potential (BP) was used for the index of dopamine D2 receptor binding. The BP value was significantly lower, by about 12.5%, in the anterior cingulate cortex in drug-naive patients with schizophrenia than in healthy controls. A significant negative correlation was observed between BP in the anterior cingulate cortex and the positive symptom score on Brief Psychiatric Rating Scale. The lower BP values indicate fewer D2 receptors in the an...Continue Reading

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Related Concepts

FLB 457, hydrobromide, (S)-isomer
Functional Cerebral Localization
Cingulate Cortex
Factor Construct Rating Scales (Fcrs)
Pyrrolidines
Salicylamides
Schizophrenia
Schizophrenic Psychology
Tomography, Emission-Computed
Dopamine D2 Receptor

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