Decreased dopamine transporter and receptor ligand binding in Parkinsonism with diabetic uremic syndrome

Annals of Nuclear Medicine
Kazuhiro IshiiAkira Tamaoka

Abstract

Here, we describe the case of a 47-year-old man with bilateral striatal lesions with diabetic uremia. Following 4 years of hemodialysis, the patient experienced sudden onset of rigidity, bradykinesia, gait disorder, and postural instability. Symptoms were remediated 2 months later, and were no longer responsive to levodopa approximately 1 year after the onset. Brain magnetic resonance imaging (MRI) during the acute phase showed T 2-weighted high signal edematous lesions in the bilateral striatum, subsequently developing into vacuolated lesions. A positron emission tomography (PET) scan using ((11)C)-labeled 2-carbomethoxy-3-(4-fluorophenyl) tropane [((11)C) CFT] and ((11)C)-labeled raclopride [((11)C) RAC] revealed significant decreases bilaterally in pre- and postsynaptic functions of the dopaminergic neurons. When we experience a case with bilateral putaminal destruction resulting in Parkinsonism, examination of the function of doperminergic neurons and dopamine receptors using molecular imaging is useful to predict levodopa response and prognosis.

References

Apr 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·I TomitaT Yoshimura
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·M C Prevett, M N Rossor
Mar 7, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Joong-Seok KimYong-An Chung
Aug 21, 2003·Journal of Neurology·Han-Cheng Wang, Shih-Jung Cheng
May 12, 2005·Clinical Neurology and Neurosurgery·Chiara CupidiVincenzo La Bella
Nov 1, 2005·Parkinsonism & Related Disorders·Phil Hyu LeeHeung Soo Kim
May 16, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Taik-Kun KimHae Young Seol
Jan 18, 2008·Nephrology·Jordan Y Z LiAlex P S Disney
Feb 17, 2009·Clinical Neurology and Neurosurgery·Chang Hyo YoonGee Sung An
Dec 22, 2009·Journal of the Neurological Sciences·Arunodaya GujjarAbdullah Al-Asmi
Nov 28, 2012·Case Reports in Neurology·Hipólito NzwaloCarlos Basílio
Mar 26, 2013·Rinshō shinkeigaku = Clinical neurology·Yoshiko NishimuraKuniaki Otsuka

❮ Previous
Next ❯

Citations

Oct 13, 2020·Movement Disorders Clinical Practice·Suvorit S Bhowmick, Anthony E Lang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved