Abstract
Here, we describe the case of a 47-year-old man with bilateral striatal lesions with diabetic uremia. Following 4 years of hemodialysis, the patient experienced sudden onset of rigidity, bradykinesia, gait disorder, and postural instability. Symptoms were remediated 2 months later, and were no longer responsive to levodopa approximately 1 year after the onset. Brain magnetic resonance imaging (MRI) during the acute phase showed T 2-weighted high signal edematous lesions in the bilateral striatum, subsequently developing into vacuolated lesions. A positron emission tomography (PET) scan using ((11)C)-labeled 2-carbomethoxy-3-(4-fluorophenyl) tropane [((11)C) CFT] and ((11)C)-labeled raclopride [((11)C) RAC] revealed significant decreases bilaterally in pre- and postsynaptic functions of the dopaminergic neurons. When we experience a case with bilateral putaminal destruction resulting in Parkinsonism, examination of the function of doperminergic neurons and dopamine receptors using molecular imaging is useful to predict levodopa response and prognosis.
References
Apr 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·I TomitaT Yoshimura
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·M C Prevett, M N Rossor
Mar 7, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Joong-Seok KimYong-An Chung
Aug 21, 2003·Journal of Neurology·Han-Cheng Wang, Shih-Jung Cheng
May 12, 2005·Clinical Neurology and Neurosurgery·Chiara CupidiVincenzo La Bella
Jun 28, 2005·Clinical Radiology·Y-H Lee
Aug 12, 2005·Internal Medicine·Kyoko OkadaJun Hayashi
Nov 1, 2005·Parkinsonism & Related Disorders·Phil Hyu LeeHeung Soo Kim
May 16, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Taik-Kun KimHae Young Seol
Jan 18, 2008·Nephrology·Jordan Y Z LiAlex P S Disney
Jan 1, 2009·Synapse·Kenji IshibashiKiichi Ishiwata
Feb 17, 2009·Clinical Neurology and Neurosurgery·Chang Hyo YoonGee Sung An
Apr 22, 2009·Annals of Nuclear Medicine·Yi-Chung WuJiunn-Tay Lee
Dec 22, 2009·Journal of the Neurological Sciences·Arunodaya GujjarAbdullah Al-Asmi
Sep 6, 2012·BMJ Case Reports·Yasutaka TajimaYu-Ichiro Fukazawa
Nov 28, 2012·Case Reports in Neurology·Hipólito NzwaloCarlos Basílio
Mar 26, 2013·Rinshō shinkeigaku = Clinical neurology·Yoshiko NishimuraKuniaki Otsuka