Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression

Brain Research
G G KinneyP Feng

Abstract

Although the biological cause of endogenous depression is unknown, one commonly held hypothesis proposes that depression results, in part, from decreased central serotonin (5-HT) neurotransmission. Previous research found that clomipramine (CLI) treatment of neonatal rats produced, in adult rats, a variety of behavioral and physiological dysfunctions resembling those found in human endogenous depression. It was later reported that adult CLI-treated rats exhibited a decreased discharge of 5-HT neurons in the dorsal raphe nucleus (DRN) compared with control rats. This finding, however, was not replicated in subsequent studies that detected differences in DRN receptor function. Several factors were identified that may have contributed to the inability of the latter studies to detect CLI vs. control differences in DRN firing rates and interspike interval histograms (ISIH). Among these were the anesthetic used, the age at which the adult rats were tested, and the location of the recording electrode. The present study controlled these variables by using chloral hydrate anesthesia, testing 'depressed' rats at both 2 and 3 months of age, and verifying electrode location using standard histological techniques. We found that DRN unit fir...Continue Reading

Citations

Jan 10, 2018·Frontiers in Cellular Neuroscience·Chen ZhaoHailin Zhang
Dec 27, 2018·The European Journal of Neuroscience·Matthew E GloverSarah M Clinton
Jun 20, 2008·Journal of Psychopharmacology·P FengK P Strohl
Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia C LemosSheryl G Beck
Dec 30, 2011·Sleep & Breathing = Schlaf & Atmung·Angela L McDowellPingfu Feng
May 31, 2002·Journal of Gerontological Nursing·Doris Noel Ugarriza
Jun 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francis Rodriguez BambicoGabriella Gobbi
May 12, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Matthew E Glover, Sarah M Clinton
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Jul 10, 2008·The International Journal of Neuropsychopharmacology·Thibault RenoirLaurence Lanfumey
Sep 3, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepika SuriMark S Ansorge
Jul 18, 2017·Birth Defects Research·Jay A GingrichMyrna M Weissman

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