Decreased emotional reactivity of rats exposed to repeated phase shifts of light-dark cycle

Physiology & Behavior
Monika OkuliarovaMichal Zeman

Abstract

Disturbed light-dark (LD) cycles are associated with circadian disruption of physiological and behavioural rhythms and in turn with an increased risk of disease development. However, direct causal links and underlying mechanisms leading to negative health consequences still need to be revealed. In the present study, we exposed male Wistar rats to repeated phase shifts of LD cycle and analysed their ability to cope with mild emotional stressors. In experiment 1, rats were submitted to either a regular 12:12 LD cycle (CTRL rats) or 8-h phase delay shifts applied every 2days for 5weeks (SHIFT rats). Subsequently, the behaviour was examined in the open-field, black-white box and elevated plus maze tests. In experiment 2, changes in blood pressure (BP), heart rate (HR) as well as the activity of autonomic nervous system were measured in telemeterised rats in response to open-field and black-white box tests before and after 5-week exposure to shifted LD regime. Locomotor activity was consistently higher in SHIFT than CTRL rats in in the open-field and black-white box tests. Interestingly, in the elevated plus maze, SHIFT rats displayed increased risk assessment and decreased grooming compared to CTRL rats. Anxiety measures were affec...Continue Reading

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Citations

Jul 28, 2016·Chronobiology International·Michal ZemanMonika Okuliarova
Dec 13, 2017·Neural Plasticity·Chelsea A Vadnie, Colleen A McClung
Jan 11, 2020·Frontiers in Behavioral Neuroscience·Kimberly M CapriJoseph A Seggio
Nov 30, 2020·The European Journal of Neuroscience·Elizabeth A ShupeSarah M Clinton

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